AIM ETA receptor antagonists reverse opioid tolerance but the involvement of ETB receptors is unknown. In morphine or oxycodone tolerant mice we investigated (1) the effect of ETB receptor agonist, IRL-1620, on analgesic tolerance; (2) changes in expression of the brain ETA and ETB receptors; and (3) alterations in the brain VEGF, NGF, PI3K and notch-1 expression. MAIN METHODS Body weight, bo...

Hummingbird participated in the WebCLEF mixed monolingual retrieval task of the Cross-Language Evaluation Forum (CLEF) 2006. In this task, the system was given 1939 known-item queries, and the goal was to find the desired page in the 82GB EuroGOV collection (3.4 million pages crawled from government sites of 27 European domains). The 1939 queries included 124 new manually-created queries, 195 m...

Bile acids (BA) are essential modulators of lipid, glucose, and cholesterol homeostasis, but they exert cytotoxic effects in the cholestatic liver. Glucuronidation, catalyzed by the UDP-glucuronosyltransferase (UGT) enzymes is a pharmacologically relevant BA detoxification process. The present study characterized the BA-conjugating activity of the little-studied human UGTs of subfamily 2A: UGT2...

The growth of a panel of eight different human glioblastoma cell lines was examined in a human tumor cloning assay in agar, a tritiated thymidine uptake assay, and by counting cell numbers, in cultures performed in the absence or presence of increasing concentrations (1 to 100 ng/ml) of recombinant human stem cell factor (SCF). Growth of 7 of 8 cell lines was not significantly and reproducibly ...

The growth of a panel of eight different human glioblastoma cell lines was examined in a human tumor cloning assay in agar, a tritiated thymidine uptake assay, and by counting cell numbers, in cultures per formed in the absence or presence of increasing concentrations (1 to 100 ng/ml) of recombinant human stem cell factor (SCF). Growth of 7 of 8 cell lines was not significantly and reproducibly...

Endothelins (ETs) act through two receptors, namely ET(A) and ET(B). In the cardiovascular system, the activation of both receptors leads to vasoconstriction. However, ET(B) receptors also mediate endothelium-dependent vasodilatation and clearance of plasma ET-1. With regard to these latter properties, we wanted to assess the contribution of ET(B) receptors and the effects of selective and mixe...

We showed previously that subcutaneous injection of the injury-associated peptide mediator endothelin-1 (ET-1) into the rat plantar hindpaw produces pain behavior and selective excitation of nociceptors, both through activation of ET(A) receptors likely on nociceptive terminals. The potential role of ET(B) receptor activation in these actions of ET-1-has not been examined. Therefore, in these e...

At the end of World War II, people considered Iceland an underdeveloped country. The use of IBM punched card systems started in 1949. The first computers appeared in 1964. Then the University of Iceland acquired an IBM 1620 “scientific” computer. The first computer language used to instruct engineers and scientists was FORTRAN II. The subsequent development gives an interesting picture of the a...

This article investigates the role of the medical examination in municipal poor relief programmes between 1570 and 1620. Documents from the city of Nördlingen, a community of approximately 10,000 people in 1600, suggest that municipal facilities addressed a range of serious illnesses for a wide spectrum of the population. Practitioners were influenced by their Galenic medical milieu but ultimat...

252001-1 Using a unitary extension of chiral perturbation theory with a lowest-order s-wave SU(3) chiral Lagrangian we study low-energy meson-baryon scattering in the strangeness S 2 sector. A scattering-matrix pole is found around 1605 MeV which corresponds to an s-wave resonance with JP 1=2 . We identify this resonance with the 1620 state, quoted by the Particle Data Group with I 1=2 but with...