The purpose of this study was to determine whether a 4-week consumption of 1.5L per day of drinking water containing monochloramine at a concentration of 2 ppm (ppm = mg/L) or 15 ppm under controlled conditions would alter parameters of lipid or thyroid metabolism in healthy men. Forty-eight men completed an 8-week protocol during which diet (600 mg cholesterol per day, 40% calories as fat) and...

The permissible limit of arsenic content in drinking water is 0.05 ppm, whereas, in many parts of West Bengal the arsenic level in drinking water is 0.1 ppm, frequently 0.3 ppm and even 3.0 ppm, though rarely. In order to assess possible risk to brain function by drinking such water, rats were given arsenic mixed in drinking water at the above four concentrations for 40 days. There was increase...

BACKGROUND Knowledge of fluoride levels in drinking water is of importance in dental public health, yet this information is lacking, at national level, in Nigeria. OBJECTIVE To map out fluoride levels in drinking water sources in Nigeria. MATERIALS AND METHODS Fluoride levels in drinking water sources from 109 randomly selected Local Government Areas (LGAs) in the 6 Nigerian geopolitical zo...

Brain, liver, kidney and muscles demonstrate significant changes in essential trace element (Cu, Zn, Mn and Fe) level in adult female mice given 30, 60 and 120 ppm sodium fluoride (NaF) in drinking water. These changes involve excess removal or accumulation of these trace elements in respective tissues. Changes observed were dose dependent and significant at 120 ppm NaF concentration in drinkin...

BACKGROUND To determine the severity of dental fluorosis in selected populations in Chiang Mai, Thailand with different exposures to fluoride and to explore possible risk indicators for dental fluorosis. METHODS Subjects were male and female lifetime residents aged 8-13 years. For each child the fluoride content of drinking and cooking water samples were assessed. Digital images were taken of...

We examined the effect of lactational exposure to tributyltin on innate immunodefenses in the F1 generation using in vivo and in vitro experiments. Pregnant C57BL/6 mice were given drinking water containing 0, 15, or 50 microg/ml of tributyltin chloride (TBTCl) from parturition to weaning. At weaning time, offspring were inoculated with Escherichia coli K-12, and bacterial clearances from the p...

Embryotoxicity and Fetotoxicity of Inhaled or Ingested Vinylidene Chloride in Rats and Rabbits. MURRAY, F. J., NITSCHKE, K. D., RAMPY, L. W., AND SCHWETZ, B. A. (1979). Toxicol. App/. Pharmacal. 49, 189-202. The teratogenic potential of inhaled or ingested vinylidene chloride was evaluated in Sprague-Dawley rats and New Zealand white rabbits. Both species were exposed to the test material by in...

Broiler breeder hens were used to determine the effect of drinking water containing a low concentration of a chemical mixture (arsenic, 0.8 ppm; benzene, 1.3 ppm; cadmium, 5.1 ppm; lead, 6.7 ppm; and trichloroethylene, 0.65 ppm) and a high (10 times greater than the low concentration of the chemical mixture) levels of the chemical mixture. These chemicals are present in ground water near hazard...

Spina bifida, a congenital deformity of the posterior wall of vertebrae of the spine, is a midline defect of skin, vertebral arches and neural tube, usually in the lumbosacral region. Its incidence is reported to be 0.2 to 0.4 per 1000 live births. Various hypotheses have been put forward as etiological factors for spina bifida including consumption of potato affected by blight and hardness of ...

Animal studies and a single human epidemiological study have suggested that chlorine in drinking water may raise the level of blood cholesterol. The purpose of this study was to determine whether a 4-week exposure to drinking water chlorine (1.5 L per day) at a concentration of 20 ppm (ppm = mg/L) under controlled conditions would alter circulating parameters of lipid metabolism in healthy huma...