in this study, independent variables were time (1-15 min0, temperature (25-45) and power of ultrasound. results showed that time of ultrasound was linear (p

Circulating lipoproteins may offer interesting properties as therapeutic carriers for cytokines and hormones, in terms of both stability and bio-distribution. The fusion of apolipoprotein A-I with interleukin-15 (IL-15) targets the latter to high-density lipoproteins (HDLs). The bioactivity of this chimera can be further enhanced by creating triple fusions with IL-15 receptor α domain involved ...

One artifact from my childhood in the 1960’s that I still remember vividly is the series of plastic slidingblock puzzles manufactured by The Roalex Company of Forest Hills, NY (no relation to the maker of fine timepieces). These consisted of a high-quality plastic puzzle glued to a piece of cardboard containing information about the puzzle. Most of their sixty or so different designs were based...

We show that the mixing time for the fifteen puzzle in an n× n torus is on the order of n logn.

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In the course of our chemical screening program for novel metabolites by LC-MS monitoring, we isolated a new aspochracin derivative, JBIR-15 (1), together with aspochracin, from the culture broth of a sponge-derived fungus, Aspergillus sclerotiorum Huber Sp080903f04. The structure of 1 was determined to be N-demethyl aspochracin at the alanyl residue on the basis of extensive NMR and MS analyses.

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I was very honored to receive the University of California, San Francisco, and the International Society of Pharmacometrics Lewis Sheiner lecturer award in May 2013. In the present perspective, I outline the main points of my lecture at the American Conference of Pharmacometrics (slides in Supplementary Material 1). I first emphasize the scientific contributions of Lewis Sheiner as a quantitati...