Antisense oligonucleotides represent a promising class of antiviral agents. ISIS 14803 is a 20-unit phosphorothioate oligodeoxynucleotide that inhibited hepatitis C virus (HCV) replication and protein expression in cell culture and mouse models. A Phase I dose-escalation clinical study of ISIS 14803 was performed in 24 patients with HCV genotype 1 chronic hepatitis C. The patients received 0.5,...

Epidemiological data describing bovine herpesvirus 1 (BoHV-1) infection in Brazilian cattle herds are scarce. A cross-sectional study was conducted in the state of Paraná between December 2001 and July 2002 with the objective of estimating the apparent prevalence of BoHV-1-seropositive herds and animals and identifying the potential risk factors for infection in farms with breeding animals in t...

STUDY OBJECTIVE To examine socioeconomic gradients in mortality in adult women and their husbands in Bangladesh, paying particular attention to the independent effects of the educational status of each spouse. DESIGN Historical cohort study. SETTING Matlab, a rural area 60 km south east of Dhaka, the capital of Bangladesh. PARTICIPANTS 14803 married women aged 45 or over and their husband...

In this issue of Annals Oncology, Tempero et al.1Tempero M. Oh D.-Y. Tabernero J. al.Ibrutinib in combination with nab-paclitaxel and gemcitabine for first-line treatment patients metastatic pancreatic adenocarcinoma: phase III RESOLVE Study.Ann Oncol. 2021; 32: 600-608Abstract Full Text PDF Scopus (19) Google Scholar report results the trial ibrutinib added to ductal adenocarcinoma (PDAC). glo...

The transferrin receptor (CD71) is known as a for IgA1 on mesangial cells, but the role of CD71 in IgA nephropathy (IgAN) unknown. We studied clinical implication 282 patients with biopsy-proven IgAN (2005–2018). transcript and protein expression glomerular was determined by real-time polymerase chain reaction immunohistochemistry. Ten subjects microscopic hematuria only no evidence histologic ...