Epigeneticmechanisms involved in theestablishment of lungepithelial cell lineage identities during development are largely unknown. Here, we explored the role of the histonemethyltransferaseEzh2 during lung lineage determination. Loss of Ezh2 in the lung epithelium leads to defective lung formation and perinatal mortality. We show that Ezh2 is crucial for airway lineage specification and alveol...

Juvenile localized scleroderma, also known as morphea, is the more frequent subtype of scleroderma in childhood. It comprises a group of distinct conditions which involve the skin and subcutaneous tissues. They range from very small plaques of fibrosis involving only the skin, to diseases which may cause significant functional and cosmetic deformity. The most widely used classification divides ...

INTRODUCTION Studies employing serological, DTH or conventional PCR techniques suggest a vast proportion of Leishmania infected individuals living in regions endemic for Visceral Leishmaniasis (VL) remain asymptomatic. This study was designed to assess whether quantitative PCR (qPCR) can be used for detection of asymptomatic or early Leishmania donovani infection and as a predictor of progressi...

BENEDETrO REGUARDATI was a physician and a diplomat.' His medical skill, shared by his younger son, Dionisio, was an inherited calling, for he came from the stock of the Norcini, medicine men, renowned throughout the ages for traditional skill in magic and healing. In his own lifetime Reguardati is said to have 'greatly increased the glory of his family' acquired in the past by his ancestors in...

Autologous skin substitute production for severe burn patients requires particular attention to culture conditions in order maintain stem cells, as various factors can affect their preservation and give variable clinical results. The goal of this study was create a database from all the data medical records available since beginning LOEX’s activities find which keratinocytes fibroblasts. With r...