Trimethoprim (TMP) has been widely used since the 1960s, both alone and in combination with sulfamethoxazole. Unfortunately, information regarding the role that cytochrome P450 enzymes (P450s) play in the formation of TMP primary metabolites is scarce. Hence, we undertook in vitro studies to identify and more fully characterize the P450s that catalyze formation of six TMP primary metabolites: T...

Synthesis and Photochemical Cyclization of a Novel EnyneCarbodiimide Michael Schmittel,* David Rodríguez 1 and Jens-Peter Steffen FB 8 OC1 (Chemie und Biologie), Universität Siegen, Adolf-Reichwein-Strasse, D-57068 Siegen, Germany. Tel. (+49)-271-4356, Fax (+49) 271-3270. E-mail: [email protected]. 1 Present address: Facultad de Química, Universidad de Santiago de Compostela, Spain...

www.sciencemag.org (this information is current as of April 15, 2008 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/298/5597/1372 version of this article at: including high-resolution figures, can be found in the online Updated information and services, found at: can be related to this article A list of selected additional a...

2006;81:1372-1378 Ann Thorac Surg Remppis, Maria Pritsch, Falk-Udo Sack, Siegfried Hagl and Philipp A. Schnabel Achim Koch, Evgeniy Palchyk, Nikolaus Gassler, Thomas J. Dengler, Andrew Cryopreserved Endomyocardial Biopsies Early and Late After Heart Transplant Expression of Platelet-Derived Growth Factor and Fibroblast Growth Factor in http://ats.ctsnetjournals.org/cgi/content/full/81/4/1372 lo...

We show that the linear cryptanalytic attack on RC5 that was published by Kaliski and Yin at Crypto’95 does not work as expected due to the failure of some hidden assumptions involved. Then we present new linear attacks on RC5. Our attacks use the same linear approximation as the one used by Kaliski and Yin. Therefore, the plaintext requirement of our attack is around 4w2r−2 which is impractica...

The standard technique to attack triple encryption is the meet-in-the-middle attack which requires 2 encryption steps. In this paper, more efficient attacks are presented. One of our attacks reduces the overall number of steps to roughly 2. Other attacks optimize the number of encryptions at the cost of increasing the number of other operations. It is possible to break triple DES doing 2 single...

ion reactions reach their maximum rates, however, in the high-temperature region, where thermal decomposition reactions are also most active. Formation and Consumption of Other Olefins. Despite the model-dependent differences in reactions of heptene isomers, the chemistry of other olefins is very similar for all three mechanisms, especially for larger olefins. Reactions that involve oxygenated ...

, 1372 (2013); 342 Science et al. Nicolas Rohner for Loss of Eyes in Cavefish Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained b...