Down syndrome (DS) is the most common chromosomally caused form of mental retardation and is caused by trisomy of chromosome 21. The over-expression of genes located on the trisomic region has been assumed to be responsible for the phenotypic abnormalities of DS, but this hypothesis has not been confirmed fully and the very existence of gene dosage effects has been called into question. We have...

Anticancer agent 6-mercaptopurine (6MP) has been in use since 1953 for the treatment of childhood acute lymphoblastic leukemia (ALL) and inflammatory bowel disease. Despite being available for 60 years, several aspects of 6MP drug metabolism and pharmacokinetics in humans are unknown. Molybdoflavoenzymes such as aldehyde oxidase (AO) and xanthine oxidase (XO) have previously been implicated in ...

Sao Paulo Med J. 2008;126(4):220-2. O R IG IN A L A R T IC L E José Eduardo Vasconcelos Fernandes Maria Isete Fares Franco Reinaldo Kenji Suzuki Nelson Mattos Tavares Sansom Henrique Bromberg Intestinal metaplasia in gallbladders: prevalence study Postgraduate program for surgical gastroenterology, Hospital do Servidor Público Estadual de São Paulo, São Paulo, Brazil CONTEXT AND OBJECTIVE: Gall...

Minipigs represent a good animal model because of the physiologic and anatomic similarities they share with humans. Three cytochrome P450 (CYP) 3A isozymes, CYP3A22, CYP3A29, and CYP3A46, have recently been reported to be expressed in Bamaminipigs, which have limited data relating to their metabolic characteristics. In the present study, Bama minipig CYP3A22, CYP3A29, and CYP3A46 were recombina...

Minipigs represent a good animal model because of the physiologic and anatomic similarities they share with humans. Three cytochrome P450 (CYP) 3A isozymes, CYP3A22, CYP3A29, and CYP3A46, have recently been reported to be expressed in Bamaminipigs, which have limited data relating to their metabolic characteristics. In the present study, Bama minipig CYP3A22, CYP3A29, and CYP3A46 were recombina...

Inheritance of plant height, pod length, pod width, seed length and seed width was studied in a set of crosses grown during rabi 2007-08. F2 phenotypic data for plant height was a good fit to a phenotypic ratio of 1:4:6:4:1 and 1:2:1 respectively in two crosses studied indicating the involvement of more than two genes. Segregation of pod length in F2 generation of the cross ICGV 00350 x K 1340,...

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1340 (2011).

Several characteristics inherent to experimental ecosystems were examined for their influence on ecological processes in five cylindrical indoor benthic–pelagic enclosures of different size and shape. Ecosystem development diverged significantly among the mesocosm dimensions even though environmental parameters such as surface photosynthetically available radiation (400–700 nm), turbulence inte...