Ototoxicity is known to cause permanent loss of vestibule function through degeneration of sensory hair cells (HCs). However, functional recovery has been reported during washout after chronic ototoxicity, although the mechanisms underlying this reversible dysfunction are unknown. Here, we study this question in rats chronically exposed to the ototoxic compound 3,3′-iminodipropionitrile (IDPN)....

CETP (cholesteryl ester transfer protein) and HL (hepatic lipase) play a role in the metabolism of plasma lipoproteins, but the effects of CETP and LIPC (gene encoding HL) genotypes on coronary atherosclerosis may be dependent on LDL (low-density lipoprotein)-receptor activity. Recently, the -1337 C>T polymorphism in the CETP gene has been reported in REGRESS (Regression Growth Evaluation Stati...

(Weatherley and Gill, 1987). Muscle fibres reach a maximum diameter, which is dictated by metabolic demands and diffusional constraints related to nutrient assimilation and/or metabolite removal. An important consequence of indeterminate growth is that the number of fibres needs to increase throughout much of the life cycle as the muscle mass increases, involving a prolonged period of postembry...

Rev Esp Cardiol 2002;55(12):1337-4

Carbamoyl-phosphate synthase I (pig liver) is modified at the cysteine residues 1327 and 1337 (numbered according to the rat sequence) in the presence of 5 mM-N-acetyl-L-glutamate with enhanced rate. ATP/Mg2+ (greater than or equal to 5 mM) protects against alkylation of these two cysteines and loss of activity. According to the results obtained by limited proteolysis of monobromobimane-modifie...

Department of Bioscience, School of Science and Technology, Kwansei Gakuin University, Sanda 669-1337, Japan; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607; Research Center for Environmental Bioscience, School of Science and Technology, Kwansei Gakuin University, Sanda 669-1337, Japan; Department of Molecular Biotech...