Ornidazole [R,S-1-chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)propan2-ol] is a chiral 5-nitroimidazole class antimicrobial agent. This study aimed to investigate the principal metabolic pathway of ornidazole in humans and identify the major enzymes involved. A total of 19 metabolites were identified in human urine collected from patients with hepatobiliary diseases after an intravenous drip inf...

At many excitatory and inhibitory synapses throughout the nervous system, postsynaptic currents become faster as the synapse matures, primarily owing to changes in receptor subunit composition. The origin of the developmental acceleration of AMPA receptor (AMPAR)-mediated excitatory postsynaptic currents (EPSCs) remains elusive. We used patch-clamp recordings, electron microscopic immunogold lo...

The first examples of thermally stable molecular dihydrogen adducts of nickel were synthesized from their dinitrogen adduct precursors, which are themselves among the first examples of Ni(II)-N2 complexes. The minimal activation of the bound N2 moieties suggests that these adducts are stabilized predominantly through s-donation from the adduct to the electrophilic metal center. We further show ...

Although stochastic programming is a powerful tool for modeling decisionmaking under uncertainty, various impediments have historically prevented its widespread use. One key factor involves the ability of non-specialists to easily express stochastic programming problems as extensions of deterministic models, which are often formulated first. A second key factor relates to the difficulty of solv...

The International Gamma-Ray Astrophysics Laboratory (INTEGRAL) is discovering hundreds of new hard X-ray sources, many of which remain unidentified. We report on optical spectroscopy of five such sources for which X-ray observations at lower energies (∼0.5–10 keV) and higher angular resolutions than INTEGRAL have allowed for unique optical counterparts to be located. We find that IGR J16426+653...

The laser plays a significant role in the lung parenchyma sparing resection for pulmonary neoplasms. The high performance Nd: YAG laser system emitting the 1318 nm wavelength exclusively up to a power of 120 W was used, consisting of the thin flexible quartz fibres (400 μm) with low water content and a four lens focusing handpiece. The Nd:YAG 1318 nm wavelength laser system enables thoracic sur...

IGR J18214-1318, a Galactic source discovered by the International Gamma-Ray Astrophysics Laboratory, is a high-mass X-ray binary (HMXB) with a supergiant O-type stellar donor. We report on the XMM-Newton and NuSTAR observations that were undertaken to determine the nature of the compact object in this system. This source exhibits high levels of aperiodic variability, but no periodic pulsations...

and/or antioxidant secondary metabolites, for example, carneic acids A—B, cohaerins C—F, daldinins C—F, ramulosin, and sassafrins A—D. During our ongoing search for biologically active metabolites from the endophytic fungi, the broth extract of the xylariaceous fungus PSU-A80, isolated from the leaves of Garcinia atroviridis, showed the antioxidant activity in 1,1-diphenyl-2-picrylhydrazyl (DPP...