Altered expression of microRNAs has been strongly implicated in human cancers, and growing evidence is emerging that a number of miRNAs are downregulated in cancer associated with CpG island hypermethylation. Although pancreatic cancer is one of the most malignant human cancers, the roles of miRNAs underlying the tumorigenesis of pancreatic cancer are still poorly understood. In the present stu...

MicroRNAs (miRNAs) play an important role in cancer development and progression, altering several biological functions by affecting targets through either degradation of mRNAs or suppression of protein translation. One such miRNA, miR-1247, is downregulated in various cancers, but its biological role in non-small-cell lung cancer (NSCLC) is unknown. This study found that the expression of miR-1...

Neuroblastoma is characterized by a wide range of clinical manifestations and associated with poor prognosis when there is amplification of MYCN oncogene or high expression of Myc oncoproteins. In a previous in vitro study, we found that the glycolytic inhibitor 2-deoxyglucose (2DG) could suppress the growth of neuroblastoma cells, particularly in those with MYCN amplification. In this study, w...

BACKGROUND Epithelial-to-mesenchymal transition (EMT) is a phenomenon that allows the conversion of adherent epithelial cells to a mesenchymal cell phenotype, which enhances migratory capacity and invasiveness. Recent studies have suggested that EMT contributes to the pathogenesis of ulcerative colitis (UC). We investigated the promoter DNA methylation status of EMT-related genes in the colonic...

Given a permutation w ∈ Sn, we consider a determinantal ideal Iw whose generators are certain minors in the generic n × n matrix (filled with independent variables). Using ‘multidegrees’ as simple algebraic substitutes for torus-equivariant cohomology classes on vector spaces, our main theorems describe, for each ideal Iw: • variously graded multidegrees and Hilbert series in terms of ordinary ...

Agnieszka Teterycz-Puzio: Konrad I Mazowiecki. Kniaź wielki lacki (1187/89—31 sierpnia 1247). Kraków, Avalon, 2019, ss. 267

Here we introduce a combined experimental and descriptive approach (termed resurrection ecology) to reconstructing historical perturbations, pointing out how direct tests with sediments and hatched resting eggs complement the traditional descriptive calculation of microfossil fluxes. In the Keweenaw Waterway, a freshwater estuary off Lake Superior, turn-of-the-century copper mining impacted the...