There was an error published in Development 138, 1087-1092. ADrosophila fly strain was described as having a transgene (Khc) with mutations that produce Khc protein with four basic amino acids in the tail microtubule-binding domain changed to alanine (Fig. 1A, Fig. 4B). The identities of two of the amino acids that were changed were misreported. The correct amino acid changes are K925A (not R92...

The therapeutic effect of ME1228, a new parenteral cephalosporin, was compared with that of broad-spectrum cephems in normal and neutropenic mice infected with various species of bacteria. The results showed that ME1228 was more active than were the other cephems against infections with various pathogens.

Dysregulated miRNAs play critical roles during carcinogenesis and cancer progression. In the present study, the function of miR-1228* in regulating cancer progression was investigated in gastric cancer. Decreased expression of miR-1228* was observed in human gastric cancer tissues comparing to normal tissues. Subsequently, the role of miR-1228* was evaluated in vivo using the tumor xenograft mo...

Repetition priming is a nonconscious form of memory that is accompanied by reductions in neural activity when an experience is repeated. To date, however, there is no direct evidence that these neural reductions underlie the behavioral advantage afforded to repeated material. Here we demonstrate a causal linkage between neural and behavioral priming in humans. fMRI (functional magnetic resonanc...

Aminothiazolylacetamidocephalosporins having 1-carboxyethoxyimino groups were synthesized and found to have excellent antibacterial activities including anti-pseudomonal activity and low toxicities. Among these cephalosporins, ME1228 having (S)-1-carboxyethoxyimino substituent and being combined with an (N-ethyl-4-pyridinio)thiomethyl group at C-3 showed marked therapeutic effects against syste...

Contrary to its classic role in restraining cell proliferation, we demonstrate here a divergent function of p53 in themaintenanceof self-renewal of the nephron progenitor pool in the embryonic mouse kidney. Nephron endowment is regulated by progenitor availability and differentiation potential. Conditional deletion of p53 in nephron progenitor cells (Six2Cre;p53) induces progressive depletion o...

We know how to integrate a function over a flat region in a plane, but what if the function is defined over a curved surface? To evaluate one of these so-called surface integrals, we rewrite it as a double integral over a region in a coordinate plane beneath the surface (Figure 16.38). Surface integrals are used to compute quantities such as the flow of liquid across a membrane or the upward fo...

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