OBJECTIVES Recently, an intermediate lactose intolerance (LI) phenotype based on the lactase gene (LCT) C/T-13910 polymorphism was proposed. However, a multifactorial genesis of LI phenotypic variation including endogenous and exogenous factors cannot be ruled out. Therefore, this study was conducted to investigate a possible association between serum diamine oxidase (DAO) and LI phenotypes in ...

BACKGROUND For nearly a decade, our center performed thromboelastograms (TEGs) to analyze coagulation profiles, allowing rapid data-driven blood component therapy. After consensus recommendations for massive transfusion protocols (MTPs), we implemented an MTP in October 2009 with 1:1:1 ratio of blood (red blood cells [RBC]), plasma (fresh-frozen plasma [FFP]), and platelets. We hypothesized tha...

Erythropoietin (EPO) exhibits diverse cellular functions, including neurotrophic, anti-oxidant, anti-apoptotic, and anti-inflammatory effects in non-hematopoietic tissues. This study evaluated whether bone marrow mesenchymal stromal cells (MSCs) transduced with the EPO gene (EPO-MSCs) promoted neural cell survival and improved neurological deficits caused by ischemic stroke. EPO-MSCs stably pro...

following result. THEOREM 1. The only (n,m)eZ with n^2 and m5=4 satisfying © = ( 7 ) a r e {n> m)=(2> 4)> (6> 6)> and (21> Our binomial diophantine equation represents an elliptic curve, since it can be rewritten as a quartic polynomial being a square. Indeed, on putting u = 2/i 1 and v = 2m 3, we see at once that Theorem 1 follows from the following result. THEOREM 2. The only (u, v) e Z with ...

We present energy-resolved angular distributions of photoelectrons generated in above-threshold ionization (ATI) of nonaligned diatomic molecules N2 and O2 in high-intensity short laser pulses, with emphasis on the most energetic part of the spectra. The angular distribution for photoelectrons with energy of 10U(p) (U(p): ponderomotive energy), i.e., the plateau cutoff in ATI spectra, is found ...

Suday, Sptem er 5, 2016 MethodS and MaterialS: Sprague Dawley rats were injected subcutaneously with two HA fillers, VYC20L [20 mg/mL] or HYC-24L+ [24 mg/mL], to create a projecting bolus. Four days post-injection, recombinant human hyaluronidase (HX) or ovine hyaluronidase (VIT) were administered at varying dose levels (5U/0.1mL bolus, 10U/0.1mL bolus, and 30U/0.1mL bolus). 3D images were capt...

Forty-two compounds (series 8, 9 and 10) incorporated with diacylated piperazine have been synthesized and evaluated as novel Bcr-Abl inhibitors based on 'six-atom linker'. Five of them, 8d, 8h, 8l, 10m and 10p, displayed potent Bcr-Abl inhibitory activity comparable with Imatinib. Moreover, compounds 8e, 10q, 10s, and 10u were potent Bcr-Abl inhibitors with IC50 values at the sub-micromolecula...

Ruptured AAA •Elderly •Severe generalised abdominal pain •Back pain •Reduced GCS/collapse •Shock •Peritonitis •Expansile mass •USS abdomen if freely available •CT only if stable •Don’t delay theatre •Aim for permissive hypotension (SBP ̴100) •Activate ‘massive haemorrhage protocol’ e.g. 10U •Urgent open repair (/ EVAR if stable) Appendicitis •Young patient •Periumbilical pain initially •Moves to...

The following study aimed to determine the antimicrobial susceptibility profile of Vibrio parahaemolyticus strains from fresh and frozen oysters Crassostrea rhizophorae sold in Fortaleza-Brazil. An antibiogram was performed on 87 isolates using nine antibiotics: gentamicin (Gen 10 µg), ampicillin (Amp 10 µg), penicillin G (Pen 10U), ciprofloxacin (Cip 5 µg), chloramphenicol (Chl 30 µg), nalidix...

We found und isolated a strong bonc resorption inhibitor, hurnulone (HU), fi'om hop extract recently.i] 'E'o study the mechanism of the inhibition of bone resorpt{on, we have choscn the preTnyclocytic lcukemia ccli HL-60. Although the target cetl for the humulone molecuge is not clear, one of the candidates for the target cell is osteoclasts. 1'he celE line of osteoclasts has not been establish...