In the present study, we investigate the effects of signal to noise (SNR), slit function (FWHM), and aerosol optical depth (AOD) on the accuracy of formaldehyde (HCHO) vertical column density (HCHOVCD) using the ground-based direct-sun synthetic radiance based on differential optical absorption spectroscopy (DOAS). We found that the effect of SNR on HCHO retrieval accuracy is larger than those ...

OBJECTIVE A herbal drug combination (Dry Extract BNO 1016) has been assessed for efficacy and tolerability in patients with acute viral rhinosinusitis. METHODOLOGY In this randomised, controlled trial patients with symptom duration of up to 3 days, mild to moderate facial pain and a Major Symptom Score (MSS) between 8 and 12 were treated for 15 days with BNO 1016 or placebo (coated tablets ad...

In this paper, we present an optimized trellis coded vector quantization (TCVQ) coding system designed for the effective and robust coding of LSF spectral parameters at low bit rate. The aim of this system, called at the beginning « LSF-OTCVQ Encoder », is to achieve a low bit rate transparent quantization of LSF parameters of the US Federal Standard (FS1016) speech Codage conjoint source-canal...

Silybin, a main component of the milk thistle of Silybum marianum, has been reported to possess anticancer activity. We investigated the effects of IdB 1016, a complex of silybin with phosphatidylcholine, on the development of mammary tumors appearing spontaneously in HER-2/neu transgenic mice. The mechanisms involved in the antitumor effect of IdB 1016 were evaluated by studying the apoptosis,...

During preclinical and early phase clinical studies of drug candidates, exposure to metabolites should be monitored to determine whether safety conclusions drawn from studies in animals can be extrapolated to humans. Metabolites accounting for more than 10% of total exposure to drug-related material (DRM) in humans are of regulatory concern, and for any such metabolites, adequate exposure shoul...

A novel fractionation method, based on both particle size and settling characteristics, was employed to examine metal distributions among five fractions. In-stream and stormwater runoff samples were collected from four land use types: highway, urban, agricultural (storm event and irrigation), and natural. Highway samples contained the highest dissolved concentrations for most metals, and freshw...

Bone morphogenetic protein (BMP) signaling is crucial for the development and function of numerous organs, but its role on the function of pancreatic islets is not completely clear. To explore this question, we applied the high throughput transcriptomic analyses on the islets isolated from mice with a pancreas-specific deletion of the gene, Bmpr1a, encoding the type 1a BMP receptor. Consistentl...

Fluorescently labeled structures can be spectrally isolated and imaged at high resolution in living embryos by light sheet microscopy. Multimodal imaging techniques are now needed to put these distinct structures back into the context of the surrounding tissue. We found that the bright-field contrast of unstained specimens in a selective plane illumination microscopy (SPIM) setup can be exploit...