Abstract This account describes the strategies for synthesis of functionalized spirooxindole polycycles, including enantiomerically enriched forms, that we have developed and reported. The syntheses these complex molecules were accomplished in a few steps starting from relatively simple oxindole derivatives other reactants. Organocatalytic reactions involved kinetic resolution or dynamic transf...

The guanido group of arginine condenses with 1, Z-cyclohexanedione in alkaline aqueous medium to form a new a-amino acid. The product (1 ,2-cyclohexanedione-arginine) was shown by independent synthesis to be N5-(4-0x0-1,3diazaspiro[4.4]non 2 ylidene) L ornithine. At hydroxide concentrations of 0.2 N or higher, this was the principal product, and the reaction with free arginine and with the argi...

The selective hydrogenation of resorcinol (RES) to 1, 3-cyclohexanedione (1,3-CHD) without the addition of alkali is a big challenge. In this article, a novel reduced graphene oxide (rGO) supported Pd catalyst was prepared through co-reduction method, over which we obtained 99.9% of resorcinol conversion and 94.2% of the ever-reported highest 1,3-cyclohexanedione selectivity at 25 °C in only CH...

Three novel bismuth(III) complexes with in situ synthesized dihydroxybenzoquinone (anilic acid) ligands, namely [Bi(H(3)dhbqdc)(H(2)dhbqdc)]·2.5dmf (1), [Bi(2)(mdhbqdc)(ox)(2)(dmf)(4)] (2) and [Bi(2)(mdhbqdc)(2)(ox)(dmf)(4)] (3) (H(4)dhbqdc = 3,6-dihydroxy-2,5-benzoquinone-1,4-dicarboxylic acid; H(2)mdhbqdc = dimethyl 3,6-dihydroxy-2,5-benzoquinone-1,4-dicarboxylate, ox = oxalate, dmf = dimethy...

Under solid-state conditions, manganese(iii) acetate-mediated radical reactions of 1,3-cyclohexanedione and 5,5-dimethyl-1,3-cyclohexanedione with in situ generated imines proceeded efficiently by mechanical milling at room temperature and good to excellent yields were achieved.

Acyloxydiene-Fe(CO)3 complexes can act as enzyme-triggered CO-releasing molecules (ET-CORMs). Their biological activity strongly depends on the mother compound from which they are derived, i.e. cyclohexenone or cyclohexanedione, and on the position of the ester functionality they harbour. The present study addresses if the latter characteristic affects CO release, if cytotoxicity of ET-CORMs is...

Three dicarbonyl reagents were used to demonstrate the presence of an essential arginine residue in the NO(3) (-) uptake system from corn seedling roots (Zea mays L., Golden Cross Bantam). Incubation of corn seedlings with 2,3-butanedione (0.125-1.0 millimolar) and 1,2-cyclohexanedione (0.5-4.0 millimolar) in the presence of borate or with phenylglyoxal (0.25-2.0 millimolar) at pH 7.0 and 30 de...

In this study we examine the effects of intravenous ethyl oleate emulsions on the metabolism of native and cyclohexanedione-modified human low density lipoprotein in rabbits. Treatment produced a highly significant fall in receptor-independent catabolism as measured by the fractional clearance rate of cyclohexanedione-modified low density lipoprotein. Receptor-dependent catabolism (the differen...

Antifreeze proteins (AFPs) can produce a difference between the nonequilibrium freezing point and the melting point, termed thermal hysteresis (TH). The TH activity of an antifreeze protein (AFP) depends on the specific AFP and its concentration as well as the presence of cosolutes including low molecular mass solutes and/or proteins. We recently identified series of carboxylates and polyols as...