Previous studies identified partial inhibitors of serotonin (5-HT) transporter and dopamine transporter binding. We report here on a partial inhibitor of 5-HT transporter (SERT) binding identified among a group of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine analogs (4-[2-[bis(4-fluorophenyl)-methoxy]ethyl]-1-(2-trifluoromethyl-benzyl)-piperidine; TB-1-099). Membranes we...

Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) is a significant source of disability in the HIV-infected population. Even with stringent adherence to anti-retroviral therapy, >50% of patients living with HIV-1 will develop HAND (Heaton et al., 2010). Because suppression of viral replication alone is not enough to stop HAND progression, there is a need for an adjun...

Leaf early senescence caused by nutrition deficiency is one of the major limitation reasons in the world crop production. Potassium (K) is one of important nutrient elements in crop growth, which modifies dozens of enzyme activations and controls stomatal movement of photosynthesis. The yield and quality of maize (Zea Mays L.) have been limited due to K deficiency in plough layer soil. However,...

Long-acting anti-HIV products can substantively change the standard of care for patients with HIV/AIDS. To this end, hydrophobic antiretroviral drugs (ARVs) were recently developed for parenteral administration at monthly or longer intervals. While shorter-acting hydrophilic drugs can be made into nanocarrier-encased prodrugs, the nanocarrier encasement must be boosted to establish long-acting ...

During studies to extend the half-life of crystalline nanoformulated antiretroviral therapy (nanoART) the mixed lineage kinase-3 inhibitor URMC-099, developed as an adjunctive neuroprotective agent was shown to facilitate antiviral responses. Long-acting ritonavir-boosted atazanavir (nanoATV/r) nanoformulations co-administered with URMC-099 reduced viral load and the numbers of HIV-1 infected C...

In recent years there has been much pressure placed on system designers to verify their designs with computer simulations before committing to actual printed circuit board layouts and hardware. Simulating complex digital designs is extremely beneficial, and very often, the prototype phase can be eliminated entirely. The same is not true for most analog circuits. While simulation can give a grea...

We present high resolution radio observations of the nuclear radio emission in a sample of eight radio galaxies having Megaparsec sizes, using the European VLBI network at 18 cm. At a resolution of 25 mas we detect all the giant radio galaxies from our sample. Among themDA 240 and 1331−099 were imaged for an extended period. These observations reveal a twin-jet structure for DA 240 and one-side...

The High Energy Stereoscopic System (H.E.S.S.) observatory has carried a deep survey of the Galactic plane, in course which existence significant number ($\sim$ 78) TeV $\gamma$-ray sources was confirmed, many remain unidentified. HESS J1828-099 is point-like (Gaussian stand. dev. $<$ 0.07$^{\circ}$) unidentified source among 17 confirmed H.E.S.S. Plane Survey (HGPS) catalog. This also unique b...

We present the results of a recent reverberation-mapping campaign undertaken to improve measurements of the radius of the broad line region and the central black hole mass of the quasar PG2130+099. Cross correlation of the 5100 Å continuum and Hβ emission-line light curves yields a time lag of 22.9 −4.3 days, corresponding to a central black hole mass MBH = (3.8 ± 1.5)×10M⊙. This value supports...

ESE 099 Undergraduate Research and/or Independent Study An opportunity for the student to become closely associated with a professor in (1) a research effort to develop research skills and technique and/or (2) to develop a program of independent in-depth study in a subject area in which the professor and student have a common interest. The challenge of the task undertaken must be consistent wit...