In searching for opportunities to exploit the benefits of silicon in TRPV1 research, we tried to investigate the pharmacological effects of sila-substitution (C/Si exchange) of tert-butyl group in the MK-056 series. Compound 13a, with a 4-positioned trimethylsilanyl group on the B ring in place of tert-butyl group, exhibited the most potent antagonist activity with IC(50) values of 0.15 microM,...

*Corresponding Author: Dr. Srinivas. C, Department of Microbiology and Biotechnology, Bangalore University, Jnanabharathi Campus, Bangalore-560 056, Karnataka, India. Page| 342 Efficacy of Trichoderma asperellum against Ralstonia solanacearum under greenhouse conditions Narasimha Murthy K, Nirmala Devi D and Srinivas C* Department of Microbiology and Biotechnology, Bangalore University, Jnanabh...

S. M. Oliveira Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Campo Mártires da Pátria, 130, 1169-056 Lisbon, Portugal and MedicalConsult, SA, Campo Grande, 56-88A, 1700-093 Lisbon, Portugal N. J. Teixeira Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Campo Mártires da Pátria, 130, 1169-056 Lisbon, Portugal and Escola Superior de Tecnologia da Saúde de Lisboa, Institu...

Bacterial isolates were obtained from mortality events affecting Mytilus edulis and reported by professionals in 2010-2013 or from mussel microflora. Experimental infections allowed the selection of two isolates affiliated to Vibrio splendidus/Vibrio hemicentroti type strains: a virulent 10/068 1T1 (76.6% and 90% mortalities in 24 h and 96 h) and an innocuous 12/056 M24T1 (0% and 23.3% in 24 h ...

The sources of IceCube neutrinos are as yet unknown. multimessenger observation their emission in γ-rays can be a guide to identification, exemplified by the case TXS 0506+056. We suggest new method searching for with Imaging Air Cherenkov Telescopes from coinciding possible astrophysical neutrinos. propose that searches extended current practice only few days up one month neutrino alert. test ...

CURRENT SCIENCE, VOL. 100, NO. 4, 25 FEBRUARY 2011 476 Bhushan Patwardhan is in the Institute of Ayurveda and Integrated Medicine, Foundation for Revitalisation of Local Health Traditions, Bangalore 560 106, India; Vishnu Joglekar is in the Tilak Ayurveda Mahavidyalaya, Pune 411 011, India; Namyata Pathak is in the Kasturba Health Society, Medical Research Centre, Mumbai 400 056, India; Ashok V...

Fifteen genetically diverse parental genotypes of sunnhemp belonging to different geographical origin were assessed to evaluate general and specific combining ability of parents and cross combinations, respectively, for selecting the superior parent combination. For this, fifteen parents and their 105 F1s were grown in a Randomized Block Design (RBD) with three replications and data were collec...