[This corrects the article DOI: 10.1186/s40834-016-0016-3.][This corrects the article DOI: 10.1186/s40834-016-0011-8.][This corrects the article DOI: 10.1186/s40834-016-0009-2.][This corrects the article DOI: 10.1186/s40834-016-0010-9.][This corrects the article DOI: 10.1186/s40834-016-0008-3.].

Background: Rac is a central regulator of cancer cell migration/invasion and metastasis. Results: EHop-016 inhibits Rac activity with an IC of 1 M. EHop-016 blocks Rac interaction with the upstream effector Vav2, and inhibits downstream PAK activity, lamellipodia extension, and cell migration. Conclusion: EHop-016 is an effective Rac inhibitor. Significance: EHop-016 has potential as a metas...

The Rho GTPase Rac regulates actin cytoskeleton reorganization to form cell surface extensions (lamellipodia) required for cell migration/invasion during cancer metastasis. Rac hyperactivation and overexpression are associated with aggressive cancers; thus, interference of the interaction of Rac with its direct upstream activators, guanine nucleotide exchange factors (GEFs), is a viable strateg...

Metastatic disease still lacks effective treatments, and remains the primary cause of cancer mortality. Therefore, there is a critical need to develop better strategies to inhibit metastatic cancer. The Rho family GTPase Rac is an ideal target for anti-metastatic cancer therapy, because Rac is a key molecular switch that is activated by a myriad of cell surface receptors to promote cancer cell ...

M. Roxo-Rosa*, M. Oleastro and F. F. Vale Center for Biodiversity, Functional & Integrative Genomics (BioFIG), Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016, Lisboa, Portugal Departamento de Genética Humana, Instituto Nacional Saúde Dr. Ricardo Jorge, Av. Padre Cruz, 1649-016 Lisboa, Portugal Departamento de Doenças Infeciosas, Instituto Nacional Saúde Dr. Ricardo Jorge,...

Sugarcane, a highly productive crop, is frequently challenged by different biotic agents, such as the pokkah boeng disease that can cause drastic yield losses of up to 40%. This airborne fungal caused various Fusarium species integrated into complex. Integrating novel compounds and biological control agents paramount importance cope with these fungi in sustainable systems. In this study, we aim...

Ana Jorge Sérgio Serra Teresa Chambel LaSIGE, Faculdade de Ciências LaSIGE, Faculdade de Ciências LaSIGE, Faculdade de Ciências Universidade de Lisboa Universidade de Lisboa Universidade de Lisboa Faculdade de Ciências e Tecnologia 1749-016 Lisboa, Portugal 1749-016 Lisboa, Portugal Universidade Nova de Lisboa [email protected] [email protected] 2829-516 Caparica, Portugal ananunesjorge@gmai...

1Department of Mathematics & Statistics, Indian Institute of Technology, Kanpur 208 016, India 2Department of Mathematics, The LNM Institute of Information Technology, Jaipur 302 031, India 3TIFR Centre For Applicable Mathematics, Tata Institute of Fundamental Research, Bangalore 560 065, India 4Department of Aerospace Engineering, Indian Institute of Technology, Kanpur 208 016, India *Correspo...