OBJECTIVE GH replacement therapy currently requires daily injections, which may be inconvenient and distressing for young patients. This study determined the safety, tolerability, pharmacokinetics and pharmacodynamics of escalating single doses of a pegylated GH (NNC126-0083) developed for once-weekly administration, in children with GH deficiency (GHD). DESIGN AND METHODS Thirty children (ag...

Strain 0083 and two field isolates of H. paragallinarum were previously converted into NAD-independent organisms by the use of crude DNA extractions from naturally occurring NAD-independent H. paragallinarum isolates. Two of these transformed isolates [0083(T) and A745(T)] were used as DNA donors in another transformation experiment in which another field isolate (M85) was used as the DNA recip...

BACKGROUND Mathematical modelling of infectious disease is increasingly used to help guide public health policy. As directly transmitted infections, such as influenza and tuberculosis, require contact between individuals, knowledge about contact patterns is a necessary pre-requisite of accurate model predictions. Of particular interest is the potential impact of school closure as a means of con...

Atypical Haemophilus paragallinarum have been isolated from both laying hens and broilers suffering from typical symptoms of infectious coryza in South Africa. Re-inoculation of these bacteria into SPF chickens resulted in similar pathology. The bacteria could be successfully re-isolated from the experimentally infected chickens. Four of the isolates from layers and 3 of those from broilers wer...

1Department of Computer Science and Systems Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan 2Hyogo Prefectural Institute of Technology, Hyogo 654-0037, Japan 3Maeda Precision Mfg, Co., Ltd., Kobe 650-0017, Japan 4Hiroshima International University, Kure 737-0112, Japan 5The Advanced Materials Processing Institute Kinki Japan, Hyogo 6...

A total of 27 different isolates of Haemophilus paragallinarum were made from chickens between June 1991 and December 1992. All of these isolates were examined by ELISA, by means of a locally produced panel of three monoclonal antibodies (denoted F1, V1 and VF3). The isolates were all of the F1 antigenic type. Three of them showed a weak reaction with the F1 monoclonal antibody, while three oth...

1 Department of Plant Systematics and Geography, Warsaw University, Al. Ujazdowskie 4, 00-478 Warsaw, Poland, (Fulbright scholar at Wichita State University) 2 Computer Science Services Group, LLC, 9415 E. Harry, Suite 302, Wichita KS 67207 (also: Department of Computer. Science, Wichita State University) s Department of Computer Science, Wichita State University, Wichita, KS 67260-0083 (also: ...