The Xenopus lymphosarcoma agent is resistant to freezingthawing, freeze-drying, and antibiotics, but sensitive to heat, ether, and chloroform. It passes a 100-nui filter, and remains in the supernatant fluid following centrifugaron at 30,000 X g for 1 hr. The agent is passed from toad to toad through the water in which the Xenopus live. Phytohemagglutinin injection did not alter the latent peri...

The model system, Xenopus laevis, has been used in innumerable research studies and has contributed to the understanding of multiple cytoskeletal components, including actin, microtubules, and neurofilaments, during axon pathfinding. Xenopus developmental stages have been widely characterized, and the Xenopus genome has been sequenced, allowing gene expression modifications through exogenous mo...

We have assessed the response of many histone H3 mRNAs and an H1C mRNA in Xenopus tissue culture cells after treatment with the DNA synthesis inhibitor hydroxyurea. The amount of the histone mRNAs falls rapidly in response to the inhibitor. This response is prevented by cycloheximide. Cloned Xenopus histone genes were transfected into mouse cells and a cell line was obtained in which the Xenopu...

Wound closure in the ectoderm of Xenopus early neurulae and chick primitive-streak embryos has been studied by scanning electron microscopy (SEM). Initial gaping of the wound and a cobble-stone appearance of cells peripheral to the wound in both Xenopus and chick confirm that the ectoderm is under lateral tension at these stages. Healing is rapid: in Xenopus embryos wound closure has started wi...

The amphibian Xenopus has long been a comparative model system of choice for a number of different biological research areas, including immunology. Specifically, the evolutionary distance between amphibians and mammals, including humans, allows for the study of both species-specific adaptations, as well as conserved features of the immune system. Furthermore, the Xenopus genus includes species ...