نتایج جستجو برای: vaca c

تعداد نتایج: 1057856  

Journal: :Infection and immunity 2001
G Le'Negrate V Ricci V Hofman B Mograbi P Hofman B Rossi

Helicobacter pylori has been shown to induce chronic active gastritis and peptic ulcer and may contribute to the development of duodenal ulcer. Previous studies have shown that H. pylori mediates apoptosis of gastric epithelial cells via a Fas-dependent pathway. However, evidence for the induction of such a mechanism in intestinal epithelial cells (IEC) by H. pylori infection has not been demon...

Journal: :The Southeast Asian journal of tropical medicine and public health 2007
Kawin Leelawat Nithikoon Suksumek Surang Leelawat Usa Lek-Uthai

In order to investigate and compare the presence of Helicobacter pylori VacA in primary liver cancer specimens (12 hepatocellular carcinoma and 6 cholangiocarcinoma) and control liver specimens (7 non-primary liver cancer) from Thai patients who underwent liver resection, H. pylori VacA gene was assayed in extracted DNA by real-time polymerase chain reaction. The selected amplicons revealed hig...

2003
Rosa Caputo Concetta Tuccillo Barbara A. Manzo Raffaele Zarrilli Giampaolo Tortora Camillo Del Vecchio Blanco Vittorio Ricci Marco Romano

Purpose: Helicobacter pylori causes gastric damage and is involved in gastric carcinogenesis. Vascular endothelial growth factor (VEGF) plays a major role in gastric mucosa repair and is overexpressed in gastric cancer. We investigated: (a) whether H. pylori, and in particular H. pylori VacA toxin, affected VEGF expression in gastric epithelial cells in culture; and (b) the signal transduction ...

Journal: :Infection and immunity 2002
Hetal K Patel David C Willhite Rakhi M Patel Dan Ye Christopher L Williams Eric M Torres Kent B Marty Robert A MacDonald Steven R Blanke

The Helicobacter pylori vacuolating cytotoxin (VacA) induces the degenerative vacuolation of mammalian cells both in vitro and in vivo. Here, we demonstrate that plasma membrane cholesterol is essential for vacuolation of mammalian cells by VacA. Vacuole biogenesis in multiple cell lines was completely blocked when cholesterol was extracted selectively from the plasma membrane by using beta-cyc...

2016
Ines Pinto-Ribeiro Rui M. Ferreira Sellma Batalha Thazin Hlaing Sio In Wong Fatima Carneiro Ceu Figueiredo

Helicobacter pylori is the major triggering factor for gastric carcinoma, but only a small proportion of infected patients develop this disease. Differences in virulence observed among H. pylori strains, namely in the vacuolating cytotoxin vacA gene, may contribute to this discrepancy. Infection with vacA s1, i1 and m1 strains increases the risk for progression of gastric premalignant lesions a...

Journal: :The Journal of biological chemistry 2008
Fengsong Wang Peng Xia Fang Wu Dongmei Wang Wei Wang Tarsha Ward Ya Liu Felix Aikhionbare Zhen Guo Michael Powell Bingya Liu Feng Bi Andrew Shaw Zhenggang Zhu Adel Elmoselhi Daiming Fan Timothy L Cover Xia Ding Xuebiao Yao

Helicobacter pylori persistently colonize the human stomach and have been linked to atrophic gastritis and gastric carcinoma. Although it is well known that H. pylori infection can result in hypochlorhydria, the molecular mechanisms underlying this phenomenon remain poorly understood. Here we show that VacA permeabilizes the apical membrane of gastric parietal cells and induces hypochlorhydria....

Journal: :Infection and immunity 2006
David A G Skibinski Christophe Genisset Silvia Barone John L Telford

There are two alleles, m1 and m2, of the midregion of the vacuolating cytotoxin gene (vacA) of Helicobacter pylori which code for toxins with different cell specificities. Here we describe the construction of five chimeric strains in which regions of vacA were exchanged between the two genotypes. By analyzing the toxicity of these strains for HeLa and RK13 cells we have confirmed that a 148-ami...

Journal: :Gut 2001
M Kidd A J Lastovica J C Atherton J A Louw

BACKGROUND The development of clinically significant disease in South Africa is associated with the vacuolating cytotoxin gene (vacA) s1 genotype but not with the presence of the cytotoxin associated gene cagA. cagA occurs in >95% of South African isolates and is a variable marker for the entire cag pathogenicity island (PAI). AIM To characterise the cagPAI in South African isolates and to in...

2016
Aleksandra Djekic Anne Müller

VacA is a pore-forming toxin that has long been known to induce vacuolization in gastric epithelial cells and to be linked to gastric disorders caused by H. pylori infection. Its role as a major colonization and persistence determinant of H. pylori is less well-understood. The purpose of this review is to discuss the various target cell types of VacA and its mechanism of action; specifically, w...

2001
Sill Moo Park Joongwon Park Jae Gyu Kim Byung Chul Yoo

BACKGROUND Determination of vacA mosaicism may be important because specific Helicobacter pylori vacA genotype can be used to predict different clinical outcome. The aim of this study was to assess the relationship of vacA genotypes of Helicobacter pylori to cagA status and its development of peptic ulcer diseases in Korean patients. METHODS Gastric biopsy specimens were obtained from 53 pati...

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