A 50-year-old man presented with pedal edema and episodes of hematuria that had started 1 month before. Systemic examination revealed mild pedal edema and petechial rashes on both lower limbs, without lymphadenopathy. The urine color was noted to be milky white (Figure 1). Urine analysis showed 3þ albumin and numerous red blood cells. Urine spot protein creatinine ratio (PCR) was 14.8. Serum al...

BACKGROUND Color blindness is a common hereditary X-linked disorder. OBJECTIVE To investigate whether color blindness affects the ability to detect the presence of blood in body fluids. METHODS Ten color-blind subjects and 20 sex- and age-matched control subjects were shown 94 photographs of stool, urine, or sputum. Frank blood was present in 57 (61%) of the photographs. Surveys were done t...

A new reagent strip for the determination of leukocytes in urine (LEUKOSTIX; Ames) is described. The test is based on the esterase activity in leukocytes as a marker. Upon contact between the reagent matrix and a urine containing leukocytes, an amino acid ester is hydrolyzed by the esterase to its corresponding alcohol. The free alcohol then couples with a diazonium salt to produce a purple azo...

A 71-year-old woman in a nursing home, with indwelling urinary catheter, bedridden, presented with a purple urine collector bag. The purple urine bag syndrome is a rare condition associated with the metabolism of tryptophan by overgrowth of intestinal bacteria. The purple color is formed by a combination of indigo and indirubin produced as a result of phosphatase and sulfatase enzymatic activit...

Two patients with urinary findings suggestive of alcaptonuria were observed. One was a two-year-old girl of Turkish descent, presenting with dark-stained diapers, black ear wax, and no other stated problem. The second was a 61-year-old North American Indian woman with long-standing rheumatoid arthritis, bluish sclerae, chronic renal failure, and dark urine. Diagnosis of alcaptonuria was confirm...

taken through this procedure for Placidyl (1). Curve A shows the scan of the chromogen formed when a urine sample, collected from a person who about 3 h before had ingested one 200mg Pyridium tablet, was diluted fivefold and taken through the assay. Curve B is a similar scan of the chromogen formed when a solution containing 2 mg/dl of Placidyl was taken through the same procedure. These spectr...

Kober (1931) was the first to suggest a calorimetric test for urinary estrin. He compared the degree of red color developed after treatment with phenolsulfonic acid in a test sample with a standard cresol red solution. Cohen and Marrian (1934) modified the Kober procedure and determined the hormone content of estrone and estriol fractions by comparison with a standard curve from a set of determ...

A chromogenic Limulus amoebocyte lysate assay was evaluated as a rapid screening test for the detection of clinically significant gram-negative bacteriuria. The development of a distinctive yellow color after the addition of chromogenic substrate to the Limulus amoebocyte lysate-urine reaction mixture was used to measure greater than or equal to 10(5) gram-negative bacteria per ml. A total of 3...

Believe it or not, your urine actually reveals quite a bit about your diet and health, so kudos to you for asking the question! While it?s hard to determine the cause of, and remedy for, your dark brown smelly pee, there are a number of factors which can potentially alter urine color and smell. Some causes may be benign, while others indicate more serious health conditions (more on those in a b...