Genetic drift in animal populations has been a recognized concern for many years. Less understood is the potential for phenotypic "drift" or variation that is not related to any genetic change. Recently, stock Sprague-Dawley (Crl:CD(SD)) rats obtained from the Charles River Raleigh facility demonstrated a distinct endogenous urinary metabonomic profile that differed from historical control SD u...

This assay of angiotensin-converting enzyme is based on release of hippuric acid from a synthetic tripeptide, hippuryl-L-histidyl-L-leucine. Hippuric acid is separated and quantitated on a reversed-phase column under conditions similar to those used for assay of theophylline and acetaminophen. The method is rapid and free from interferences.

The performance of amino acids and carboxylic acids of biological importance on the corrosion of mild steel and copper in sodium chloridesolutionswas investigated. Manyofthe amino acidsare inhibitive. Aspartic acid, cysteine, cystine, threonine and histidine enhance the corrosion of mild steel. For copper, however, all t he compounds except 4-amino n-butyric acid and hippuric acid, promote corr...

Ikeda, M., and Ohtsuji, H. (1969). Brit. J. industr. Med., 26, 162-164. Hippuric acid, phenol, and trichloroacetic acid levels in the urine of Japanese subjects with no known exposure to organic solvents. Urine samples from 36 male and 30 female university students and 31 male factory workers with no known exposure to industrial organic solvents were analysed for hippuric acid, phenol, and tric...

I. S 24 perennial ryegrass was harvested at six stages of its growth from young leafy herbage to mature grass in which the seed had shed. 2. Two sheep were offered Ikg/d of each cut and two other sheep were offered 750 g/d of each cut of grass. 3. The contents of some possible precursors of the urinary aromatic acids excreted by sheep, namely, shikimic acid, quinic acid, chlorogenic acid, total...

High-speed liquid chromatography employing an ultraviolet photometric detector has been applied to the simultaneous determination of hippuric and m-methylhippuric acids in urine. Reversed-phase partition chromatography is carried out on a muBondapak C18 column with methanol-water as the eluent system. This method obviates the necessity for isolation or reaction of these acids before assay. The ...

Bedouin goats were fed on wheat straw as a single-component diet under two watering regimens, drinking once daily or once every 4 d, in order to clarify whether lignin-degradation products were absorbed, metabolized and excreted in urine. Acid-soluble lignin accounted for 220 g/kg total lignin, its digestibility was the highest (0.87) and was unaffected by water deprivation. Acid-insoluble lign...

BACKGROUND The intake of some benzoic acid-containing foods or drinks such as green tea and coffee is known to increase urinary hippuric acid (HA) concentrations, and, unless this can be accounted for, may result in false-positive findings during the biological monitoring of toluene exposure. AIMS To investigate the influence of green tea and coffee ingestion on urinary HA concentrations. M...