Matched molecular pairs (MMPs) are widely used in medicinal chemistry to study changes in compound properties including biological activity, which are associated with well-defined structural modifications. Herein we describe up-to-date versions of three MMP-based data sets that have originated from in-house research projects. These data sets include activity cliffs, structure-activity relations...

A data mining approach is introduced that automatically extracts SAR information from high-throughput screening data sets and that helps to select active compounds for chemical exploration and hit-to-lead projects. SAR pathways are systematically identified consisting of sequences of similar active compounds with gradual increases in potency. Fully enumerated SAR pathway sets are subjected to p...

Abstract Cliffs are unique ecosystems with an outstanding but relatively unknown plant diversity, harboring rare, endemic and threatened species, also rock-specialist or generalist species that can become locally common dominant on cliffs. The rising popularity of climbing represents increasing threat to cliff biota, affecting community composition potentially diminishing diversity associations...

Underwater vehicles have been extensively applied to underwater intervention missions instead of human in recent years. As the crucial equipment of underwater vehicles, underwater manipulators typically play an important role in the underwater tasks. Generally, underwater manipulators are operated manually by human with remotely operated vehicles (ROVs). A KORDI ROV with a dual teleoperated man...

Web-scale applications are heavily reliant on memory cache systems such as Memcached to improve throughput and reduce user latency. Small performance improvements in these systems can result in large end-to-end gains. For example, a marginal increase in hit rate of 1% can reduce the application layer latency by over 35%. However, existing web cache resource allocation policies are workload obli...

Recently, data collection from seabed by means of underwater wireless sensor networks (UWSN) has attracted considerable attention. Autonomous underwater vehicles (AUVs) are increasingly used as UWSNs in underwater missions. Events and environmental parameters in underwater regions have a stochastic nature. The target area must be covered by sensors to observe and report events. A ‘topology cont...