Currently, anti-PD-1/PD-L1 immunotherapy using immune checkpoint inhibitors is widely used in the treatment of multiple cancer types including lung cancer, which a leading cause death world. However, only limited proportion patients will benefit from therapy. Therefore, it importance to predict response for precision patients. Although expression PD-L1 and tumor mutation burden (TMB) are common...

  Two rare cases of extra-articular diffuse variant giant cell tumor of the tendon sheath are presented, at the elbow of a 68-year-old female and the foot of a 56-year-old male. Both patients presented with a palpable masses and marginal excision was performed; histological sections confirmed the diagnosis of extra-articular giant cell tumor. No adjuvant therapy was administered. At the last fo...

The treatment of bladder cancer is usually performed by Bacillus Calmette-Guerin (BCG) instillation. BCG therapy is a common therapeutic method with fewer side effects compared with chemotherapy, radiotherapy, etc. BCG can also inhibit the progression and recurrence of bladder cancer by inducing apoptosis pathways, arrest cell cycle, autophagy, and neutrophil extracellular traps (NETs) formatio...

Advanced melanoma is an aggressive form of skin cancer characterized by low survival rates. Less than 50% advanced patients respond to current therapies, and those that do respond, many present with tumor recurrence due resistance. The immunosuppressive tumor-immune microenvironment (TIME) remains a major obstacle in therapy. Adjuvant treatment modalities enhance anti-tumor immune cell function...

Tumor immune escape is one of the ten characteristics tumor occurrence and development. Immunotherapy targeting has achieved remarkable success in recent years. involves many factors links, which are related to changes cells themselves microenvironment, mechanism complex. At present, it still faces great challenges clinical practice. This article introduces from several aspects, including itsel...

Cancer stem cells (CSCs) are now well-established as key players in tumor initiation, progression, and therapy resistance [...]

Introduction: Superficial cancers are one of the most common in humans and animals. The use maggot therapy as an alternative treatment is expanding has achieved great success treating superficial. Maggot extracts secretions have been also demonstrated to beneficial biological effects. present study aimed perform first systematic review maggot, well its extracts, neoplasms. Methods: In current s...

Adoptive cell therapy based on chimeric antigen receptor-engineered T (CAR-T) cells has proven to be life-saving for many cancer patients. However, its therapeutic efficacy so far been restricted only a few malignancies, with solid tumors proving especially recalcitrant efficient therapy. Poor intra-tumor infiltration by and “T dysfunction” due an immunosuppressive microenvironment are key barr...