نتایج جستجو برای: tlrs
تعداد نتایج: 3428 فیلتر نتایج به سال:
gp96 is an endoplasmic reticulum chaperone for cell-surface Toll-like receptors (TLRs). Little is known about its roles in chaperoning other TLRs or in the biology of macrophage in vivo. We generated a macrophage-specific gp96-deficient mouse. Despite normal development and activation by interferon-gamma, tumor necrosis factor-alpha, and interleukin-1beta, the mutant macrophages failed to respo...
Abstract The innate immune system is equipped with multiple receptors to detect microbial nucleic acids and induce type I interferon (IFN) restrict viral replication. When dysregulated these receptor pathways inflammation in response host promote development persistence of autoimmune diseases like Systemic Lupus Erythematosus (SLE). IFN production regulated by the Interferon Regulatory Factor (...
Background: Pattern recognition receptors, especially toll-like receptors (TLRs), as the first line of defense for pathogen detection, were found to be associated with H. pylori infection and gastric cancer (GC). However, the expression levels of TLRs, i.e. TLR2 and TLR4, as the main receptors sensed by H. pylori, still remain largely ambiguous. We aimed to investigate the patterns of key tra...
Purpose of the study . To evaluate number cells with CD45 +/- phenotype expressing Toll-like receptors (TLRs) in tissues tumor, peritumoral area and resection line colon cancer (CC) various tumor locations. Materials methods The included 50 patients CC. All underwent surgery as primary treatment, tissue material was collected from patients. Expression TLRs (2, 3, 4, 8, 9) on + , - cell populati...
Chronic liver damage caused by viral infection, alcohol, or obesity can result in increased risk for hepatocellular carcinoma (HCC). Ample epidemiological evidence suggests that there is a strong synergism between hepatitis C virus (HCV) and alcoholic liver diseases (ALD). The Toll-like receptor (TLR) signaling pathway is upregulated in chronic liver diseases. Alcoholism is associated with endo...
Toll-like receptors (TLRs) are expressed on all major subsets of liver cells. Both exogenous ligands derived from pathogens, and endogenous ligands that are products of cellular injury, engage these receptors and activate aspects of innate immunity. These receptors play a role in viral and parasitic infections of the liver, in ischemia-reperfusion injury, and in toxic liver damage, promoting an...
Toll-like receptors (TLRs) initiate innate immune responses and direct subsequent adaptive immunity. They play a major role in cutaneous host defense against micro-organisms and in the pathophysiology of several inflammatory skin diseases. To understand the role of TLRs in the acquisition of immunological competence, we conducted a comprehensive study to evaluate TLR expression and function in ...
Evolutionary Dynamics of Human Toll-Like Receptors and Their Different Contributions to Host Defense
Infectious diseases have been paramount among the threats to health and survival throughout human evolutionary history. Natural selection is therefore expected to act strongly on host defense genes, particularly on innate immunity genes whose products mediate the direct interaction between the host and the microbial environment. In insects and mammals, the Toll-like receptors (TLRs) appear to p...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید