______________________________________________________________________________ In this paper the conductometric titration of propranolol hydrochloride in pharmaceutical formulations using silver nitrate as titrant is proposed. The method was based on the formation of an insoluble salt (AgCl(s)) between the chloride of propranolol hydrochloride molecule and Ag(I) ions of the titrant AgNO3. The e...

Acid or base concentrations can be determmed very rapidly by performmg an acid-base titration with coulometncally generated OHor H+ ions at a noble metal actuator electrode m close proximity to the pH-sensitive gate of an ion-sensitive field effect transistor (ISFET) The ISFET is used as the mdicator electrode to detect the eqmvalence point in the titration curve Typical values for the time nee...

Synergistic antifungal activity of 5-fluorocytosine (5-FC) and amphotericin B was studied using an abbreviated checkerboard titration scheme. 5-FC was titrated in twofold increments (100 to 0.05 mug/ml) in the absence and presence of graded increments of amphotericin B (1.0. 0.5, 0.1, 0.05, and 0.01 mug/ml) in buffered yeast nitrogen base. A limited number of experiments were performed using ex...

The precipitation of asphaltenes in two Mexican crude oils was measured using a combination of high-pressure isothermal expansion and atmospheric titration with nalkanes. Experiments were carried out from the liveand tank-oil type of samples of the same crude oils. For the oils investigated, compositional data, precipitation phase diagrams, and bubble point pressures are reported. A theoretical...

In this paper, an adaptive neuro fuzzy sliding mode based genetic algorithm (ANFSGA) controlsystem is proposed for a pH neutralization system. In pH reactors, determination and control of pH isa common problem concerning chemical-based industrial processes due to the non-linearity observedin the titration curve. An ANFSGA control system is designed to overcome the complexity of precisecontrol o...

Prothrombin (coagulation factor II) is the inactive precursor molecule of thrombin (coagulation factor IIa). Proteolytic cleavage of the peptide bond Arg320-Ile321 converts prothrombin into the two-chain thrombin precursor meizothrombin. Meizothrombin hydrolyses peptidyl substrates, but cleavage of fibrinogen is poor. Unfortunately, meizothrombin exhibits a significant autocatalytic activity an...

Sodium currents in cultured rat muscle cells converted to myoballs by treatment with colchicine were recorded using a giga-ohm seal voltage-clamp procedure in the whole-cell configuration. Geographutoxin II (GTX II), a novel polypeptide toxin from the piscivorous marine snail Conus geographus, reduces sodium currents in rat myoballs without marked alteration of the time course or voltage depend...