We showed previously that the number and time of spike-wave discharges (SWDs) were increased after intraperitoneal (i.p.) injection of lipopolysaccharide (LPS), an effect, which was completely abolished by cyclooxygenase-2 (COX-2) inhibitor indomethacin (IND) pretreatment in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. These and other results suggest that injection of LPS to genetically absence...

OBJECTIVE This the first of two articles reviewing the scientific literature on the evaluation and treatment of circadian rhythm sleep disorders (CRSDs), employing the methodology of evidence-based medicine. In this first part of this paper, the general principles of circadian biology that underlie clinical evaluation and treatment are reviewed. We then report on the accumulated evidence regard...

OBJECTIVE In order to unravel the mechanisms underlying the "sudden" onset of spontaneous absences in genetically prone subjects, we investigated the immediate precursors of spike-wave discharges (SWDs) produced in cortico-thalamo-cortical neuronal networks. METHODS A time-frequency analysis of the cortical and thalamic ECoG of WAG/Rij rats was accomplished with a continuous wavelet decomposi...

Asking citizens “the way democracy works” is the basis of a wide literature on support have for their political institutions and one most common survey items in science. Moreover, it key indicator purported global decline legitimacy. Yet, its trends, levels, dynamics are still debated, conclusions may be erroneous. In this paper, we compile unique dataset between 1973 2018 encompassing all majo...

Due to the competition for water resources, increasing efforts are done in order to use more efficiently irrigation water in agriculture. The purpose of this paper is to find out daily soil water content (SWC) dynamics during depletion cycles in order to emphasize its pattern and compare daylight vs. night (dark) and morning vs. afternoon SWC dynamics in an irrigated peach (Prunus persica [L.] ...

To characterize the genetic basis of spike-wave discharges (SWDs) detected by electroencephalography (EEG) in C3H/He mice, substrains of C3H mice were evaluated by EEG and sensitivity to ethosuximide. Crosses with the SWD-negative strain C57BL/6J were performed to map the underlying gene(s). C3H/He substrains exhibited a modest incidence (average of 19 SWDs per hour) of 7-8 Hz SWDs when at rest...

OBJECTIVES Childhood absence epilepsy (CAE) is a syndrome with well-defined electroclinical features but unknown pathological basis. An increased thalamic tonic GABA inhibition has recently been discovered on animal models (Cope et al., 2009), but its relevance for human CAE is unproven. METHODS We studied an 11-year-old boy, presenting the typical clinical features of CAE, but spike-wave dis...

OBJECTIVE Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Human patients and rat absence models show bilateral spike-wave discharges (SWD) in cortical regions. We employed diffusion tensor imaging (DTI) in rat absence models to detect abnormalities in white matter pathways connecting regions of seizure activity. METHODS We studied Wis...

Ischialgia merupakan rasa sakit yang dimulai dari punggung bawah dan menjalar ketungkai, terkadang sampai kaki. keluhan berupa nyeri di sepanjang nervus ischiadicus, L4-S3. Selain sakit, ischialgia atau sciatica ini biasanya disertai dengan saraf ada juga merasa kesemutan, kelemahan, mati kaki (Laroche & Perrot, 2013). Tujuan: Untuk memberikan informasi kepada lansia apa dimaksud bagaimana ...

Some students with autism spectrum disorder and other learning differences may have superior visual acuity, increased attentional focus, logical thinking abilities, lending to an affinity for science, technology, engineering, mathematics (STEM) fields. At the same time, economists report that, United States will experience a 28.2% increase in STEM-related jobs between 2014 2024. Although disabi...