We have studied the antibodies to sexual stage antigens of Plasmodium falciparum in human sera from Papua New Guinea where intense transmission of P. falciparum occurs as well as the less prevalent P. malariae and P. vivax. In extracts of gametes of P. falciparum we have studied the reactivity of serum antibodies with antigens labeled with 125I on the surface of the gametes as well as intracell...

The E3 19,000-dalton protein termed "E3/19K" of adenovirus type 2 binds to human class I histocompatibility antigens (HLA antigens). Human 293.12 cultured cells that express a cloned gene for the E3/19K protein show reduced levels of HLA antigens on the cell surface compared to parental 293 cells. We have transfected these cell lines with plasmid DNA containing the murine histocompatibility H-2...

The two key questions of h u m a n cancer immunology remain unresolved. These relate to whether tumor-specific antigens exist in h u m a n cancer and, if so, whether there is immunological recognition of these antigens in humans. To date, candidate h u m a n tumor-specific antigens defined by heterologous sera have, on further analysis, turned out to belong to the category of differentiation an...

This paper reviews cell surface Ags expressed on mouse hemopoietic and nonhemopoietic cells. The review will cover molecules included in the cluster of differentiation (CD) from CD1 to CD166 and lymphocyte Ag (Ly) series from Ly-1 to Ly-81 as well as some new Ags without current CD or Ly assignments. In addition to an update on mouse nomenclature, there will be a discussion of some known functi...

Many of the leukocyte cell surface molecules are known by "CD" numbers. In this Appendix, a short introduction describes the history and the use of CD nomenclature and provides a few key references to enable access to the wider literature. This is followed by a table that lists all human molecules with approved CD names, tabulating alternative names, key structural features, cellular expression...

Surface and cytoplasmic antigens in retinoblastoma were examined by antisera prepared against two tissue-cultured retinoblastoma cell lines. In addition, several other antisera, including anti-rhodopsin, anti-rod outer segment, anti-large-molecular-weight protein, anti-S, and anti-P antigen, were also utilized in a complement-dependent cytotoxicity assay in order to explore the tumor cell surfa...

The rate of appearance , in a populat ion of mouse-human heterokaryons , of cells with intermixed mouse and human surface antigens may be used to estimate the rate of lateral diffusion of the antigens in a single cell. Most he terokaryons appear to restrict diffusion of their surface antigens. These restrictions are altered by exposing either he terokaryons or their parent cells to conditions t...

Two mouse anti-human monoclonal antibodies (S3.13 and S5.7) raised against cells of acute myelogenous leukemia were found to react with antigens expressed on the surface of subsets of monocytes and lymphocytes. S3.13 precipitates a peptide of Mr 29,000, and S5.7 precipitates a peptide of Mr 20,000 present on the surface of all the cell types tested. These two surface antigens were distributed o...

Immunity against blood stage Plasmodium falciparum malaria can be passively transferred with immune gamma globulin (1), and protective antibodies appear to act against the merozoite form of the parasite (2). For vaccine development, therefore, it is important to identify and characterize the surface antigens of merozoites against which protective antibodies may be directed. We have reported the...