نتایج جستجو برای: subcutaneous human preadipocyte

تعداد نتایج: 1671344  

Journal: :Diabetes 2004
Louise Hutley Wenda Shurety Felicity Newell Ross McGeary Nicole Pelton Jennifer Grant Adrian Herington Donald Cameron Jon Whitehead Johannes Prins

Obesity, with its related problems, is recognized as the fastest growing disease epidemic facing the world, yet we still have limited insight into the regulation of adipose tissue mass in humans. We have previously shown that adipose-derived microvascular endothelial cells (MVECs) secrete a factor(s) that increases proliferation of human preadipocytes. We now demonstrate that coculture of human...

2013
Yasushi Ishijima Shin’ya Ohmori Kinuko Ohneda

Mast cells have been suggested to play key roles in adipogenesis. We herein show that the expression of preadipocyte, but not adipocyte, marker genes increases in the white adipose tissue of mast cell-deficient (Kit(W-sh/W-sh) ) mice under both obese and non-obese conditions. In vitro culturing with adipogenic factors revealed increased adipocytes differentiated from the Kit(W-sh/W-sh) stromal ...

2008
Weijun Pang Shiduo Sun Liang Bai

Foxo1 plays an important role in the integration of hormone-activated signaling pathways with the complex transcriptional cascade that promotes preadipocyte differentiation of clonal cell lines from rodents. We isolated the full-length cDNA of porcine FoxO1 gene using RACE, confirmed by visual Northern blotting. The deduced amino acids indicated 94% and 90% identities with the corresponding hum...

Journal: :Emerging Infectious Diseases 2007

Journal: :Endocrinology 2006
Julianna J Tomlinson Adèle Boudreau Dongmei Wu Ella Atlas Robert J G Haché

Glucocorticoids provide an adipogenic stimulus that is most obvious in the truncal obesity of patients with Cushing's syndrome. Glucocorticoid treatment also strongly potentiates the differentiation of human preadipocytes in culture. However, the molecular basis of these stimulatory effects remains to be defined. In this study, we provide a detailed analysis of the specific contribution of gluc...

Journal: :The Journal of clinical endocrinology and metabolism 1998
R S Bahn C M Dutton N Natt W Joba C Spitzweg A E Heufelder

It is acknowledged that the TSH receptor (TSHr) on thyroid follicular cells is the autoantigen involved in the hyperthyroidism of Graves' disease. However, whether this receptor is expressed in extrathyroidal tissues, and whether it participates directly in the pathogenesis of Graves' ophthalmopathy (GO) are unclear. We sought to detect the expression of TSHr messenger ribonucleic acid (mRNA) a...

Journal: :Biochemical and biophysical research communications 1999
C Pagès A Rey M Lafontan P Valet J S Saulnier-Blache

In the present study, we studied the involvement of A2 phospholipases (PLA2) in alpha2-adrenergic receptor-control of preadipocyte actin cytoskeleton. For that, various PLA2 inhibitors were tested on the ability of the selective alpha2-adrenergic agonist UK14304 to induce the spreading in alpha2AF2 preadipocytes. We observed that, whereas several Ca(2+)-dependent PLA2 blockers were ineffective,...

2011
Michaela Keuper Anna Dzyakanchuk Kurt E. Amrein Martin Wabitsch Pamela Fischer-Posovszky

Obesity is associated with an accumulation of macrophages in adipose tissue. This inflammation of adipose tissue is a key event in the pathogenesis of several obesity-related disorders, particularly insulin resistance. Here, we summarized existing model systems that mimic the situation of inflamed adipose tissue in vitro, most of them being murine. Importantly, we introduce our newly establishe...

Journal: :The Biochemical journal 2015
Wright Jacob Doron Rosenzweig Cristina Vázquez-Martin Suzanne L Duce Patricia T W Cohen

Glucocorticoids play an important role in the treatment of inflammation and immune disorders, despite side effects, which include metabolic derangements such as central adiposity. These studies examine the role of protein phosphatase 5 (Ppp5) in glucocorticoid receptor (GR) complexes which mediate response to glucocorticoids. Mice homozygous for inactivated Ppp5 (Ppp5D274A/D274A) exhibit decrea...

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