In response to brief glutamate exposure, NMDA receptors produce excitatory currents that have sub-maximal amplitudes and characteristically slow kinetics. The activation sequence starts when glutamate binds to residues located on the upper lobe of extracellularly located ligand-binding domains (LBDs) and then contacts lower lobe residues to bridge the cleft between the two hinged lobes. This ev...

The effect of many-body interaction in curved space is studied based on the extended Bose--Hubbard model hyperbolic lattices. Using mean-field approximation and quantum Monte Carlo simulation, phase diagram explicitly mapped out, which contains superfluid, supersolid insulator phases at various fillings. Particularly, it revealed that sizes Mott lobes shrink stabilized smaller nearest-neighbor ...