OBJECTIVE  To compare differences in mortality between women concomitantly treated with tamoxifen and selective serotonin reuptake inhibitors (SSRIs) that are potent inhibitors of the cytochrome-P450 2D6 enzyme (CYP2D6) versus tamoxifen and other SSRIs. DESIGN  Population based cohort study. SETTING  Five US databases covering individuals enrolled in private and public health insurance prog...

BACKGROUND The risk of birth defects after antenatal exposure to selective serotonin-reuptake inhibitors (SSRIs) remains controversial. METHODS We assessed associations between first-trimester maternal use of SSRIs and the risk of birth defects among 9849 infants with and 5860 infants without birth defects participating in the Slone Epidemiology Center Birth Defects Study. RESULTS In analys...

BACKGROUND Selective serotonin reuptake inhibitors (SSRIs) are one of the most commonly prescribed classes of antidepressants. Glaucoma is the second leading cause of blindness globally and iatrogenic glaucoma has been implicated across disparate medication classes. Available studies that have sought to determine the association between SSRI exposure and glaucoma have provided mixed results. Th...

OBJECTIVE To review the efficacy and safety of moclobemide in comparison with TCAs (for our purposes, "TCAs" will represent tricyclic and tetracyclic antidepressants, including maprotilin and mianserin) and selective serotonin reuptake inhibitors (SSRIs) in elderly depressed patients. METHODS The efficacy data reviewed were obtained from the following sources: 1) results of published studies ...

The selective serotonin reuptake inhibitors (SSRIs) are the most frequently prescribed antidepressant drugs, because they are well tolerated and have no severe side effects. They rapidly block serotonin (5-HT) reuptake, yet the onset of their therapeutic action requires weeks of treatment. This delay is the result of presynaptic and postsynaptic adaptive mechanisms secondary to reuptake inhibit...

We report here a patient with major depressive disorder who experienced severe adverse effects after the administration of SSRIs (serotonin selective reuptake inhibitors) without improvement of his depressive symptoms. These adverse effects disappeared and his depressive symptoms improved after discontinuation of the SSRIs and the administration of tianeptine. The patient exhibited a low value ...

I n the article " Pharmacologic treatment of depression in late life " Alastair Flint gives a thorough and comprehensive review of the treatment of depression. He mentions that to his knowledge, " only 1 trial has compared an SSRI [selective serotonin reuptake inhibitor] (sertra-line) with a secondary amine TCA [tricyclic antidepressant] (nortripty-line), and both drugs were equally well tolera...

Sir: In recent years, there have been several case reports of extrapyramidal symptoms as a result of treatment with selective serotonin reuptake inhibitors (SSRIs). These symptoms include dystonia, akathisia, and parkinsonism. In most previously reported cases, the patients had preexisting brain diseases, but some movement disorders developed after initiation of SSRI treatment in both young hea...