PURPOSE To evaluate transient, large visual acuity (VA) decreases, termed sporadic vision loss, during anti-vascular endothelial growth factor treatment for neovascular age-related macular degeneration (AMD). DESIGN Cohort within a randomized clinical trial. METHODS setting: Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). study population: Total of 1185 CATT patient...

Patients with adult onset non-familial progressive ataxia are classified in sporadic ataxia group. There are several disease categories that may manifest with sporadic ataxia: toxic causes, immune-mediated ataxias, vitamin deficiency, infectious diseases, degenerative disorders and even genetic conditions. Considering heterogeneity in the clinical spectrum of sporadic ataxias, the correct diagn...

There are sporadic task systems schedulable by EDF, which no fixed-priority (FP) algorithm can schedule successfully. For instance, it is known that while all implicit-deadline sporadic task systems with utilization at most one are EDF-schedulable on a unit-capacity uniprocessor, there are implicit-deadline sporadic task systems that are not schedulable by any FP algorithm, and have utilization...

Existing off-line schedulability analysis for real-time systems can only handle periodic or sporadic tasks with known minimum inter-arrival times. Modeling sporadic tasks with fixed minimum inter-arrival times is a poor approximation for systems in which tasks arrive in bursts, but have longer intervals between the bursts. In such cases, schedulability analysis based on the existing sporadic ta...

Hypertrophic cardiomyopathy occurs as an autosomal dominant familial disorder or as a sporadic disease without familial involvement. While missense mutations in the beta cardiac myosin heavy chain (MHC) gene account for approximately half of all cases of familial hypertrophic cardiomyopathy, the molecular causes of sporadic hypertrophic cardiomyopathy are unknown. To determine whether beta card...

BACKGROUND Primary aldosteronism (PA) is the most common endocrine form of secondary hypertension, and one of the most common subtypes of sporadic PA is aldosterone-producing adenoma (APA). Recently, two somatic mutations of the KCNJ5 gene were implicated in APA, and two germline mutations were associated with familial hyperaldosteronism III. OBJECTIVES This case-control study was designed to...

RUNX1 is a recurrently mutated gene in sporadic myelodysplastic syndrome and leukemia. Inherited mutations in RUNX1 cause familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML). In sporadic AML, mutations in RUNX1 are usually secondary events, whereas in FPD/AML they are initiating events. Here we will describe mutations in RUNX1 in sporadic AML and in FPD/AML, discu...