How the results of this project will benefit society: Abnormalities in the sense of smell have particular clinical relevance for patients with Alzheimer’s disease (AD), in whom deficits of smell identification and discrimination arise early in the course of illness, and often before the emergence of overt cognitive symptoms such as memory loss. Given the early accumulation of Alzheimer’s pathol...

After a total laryngectomy the upper and lower airways are disconnected resulting in a wide range of adverse effects, e.g. deterioration of nasal functions in breathing, loss or decrease of normal sense of smell and taste, as well as loss of normal voice. Recently, a new method that can restore the sense of smell in laryngectomized patients has been developed, the Nasal Airflow-Inducing Maneuve...

Standardized olfactory tests are now available to quantitatively assess disorders of olfaction. A Brazilian-Portuguese version of the University of Pennsylvania Smell Identification Test (UPSIT) is currently being developed specifically for the Brazilian population. The most recent Brazilian-Portuguese version of the UPSIT (UPSIT-Br2) was administered to 88 Brazilian subjects who had no history...

UNLABELLED The idiopathic Parkinson disease (IPD) is traditionally diagnosed by motor signs, but non-motor symptoms and signs are frequent and may help in the clinical diagnosis. PURPOSE To evaluate the olfactory function in Brazilian healthy subjects, patients with early-onset PD (EOPD) and late-onset PD (LOPD) using the Sniffin' Sticks odor-identification test (SST). METHOD We studied 70 ...

Objective: The authors examined the relationship between deficits in olfactory identification and duration of illness in young and elderly patients with schizophrenia. Method: Olfactory identification performance of 38 patients with schizophrenia and 40 normal subjects was compared by using the University of Pennsylvania Smell Identification Test. Results: The schizophrenic patients demonstrate...