GammaPNA oligomers having one or two repeats of the sequence AATCCC were designed to hybridize to DNA having one or more repeats of the complementary TTAGGG sequence found in the human telomere. UV melting curves and surface plasmon resonance experiments demonstrate high affinity and cooperativity for hybridization of these miniprobes to DNA having multiple complementary repeats. Fluorescence s...

Introduction: The Epstein–Barr virus (EBV) W repeats are transcribed during viral lytic reactivation, a highly oncogenic form of latency known as latency III, and a rare type of latency (Wp-restricted) that is observed in ~15% of endemic Burkitt’s lymphomas. The W repeats encode an EBV protein, EBNA-LP, whose message is produced by splicing out a short (81 nt) and long (2791 nt) intron. We prev...

expressed sequence tags simple sequence repeats (est-ssrs) are important sources for investigation ofgenetic diversity and molecular marker development. similar to genomic ssrs, the est-ssrs are usefulmarkers for many applications in genetics and plant breeding such as genetic diversity analysis, molecularmapping and cross-transferability across related species and genera. in spite of low polym...

Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein (Cas) system facilitates targeted genome editing in organisms. Despite high demand of this system, finding a reliable tool for the determination of specific target sites in large genomic data remained challenging. Here, we report SSFinder, a python script to perform high throughput detection of spec...

the identification of parental inbred lines to develop superior hybrids is a rather costly and time-consuming step in maize breeding. in some cases, pedigree information has been used to select diverse parental lines. in the case of iranian maize inbred lines, this information is not fully available. in this study we investigated the genetic distance (gd) based on simple sequence repeats (ssr) ...

MOTIVATION We consider the problem of identifying low-complexity regions (LCRs) in a protein sequence. LCRs are regions of biased composition, normally consisting of different kinds of repeats. RESULTS We define new complexity measures to compute the complexity of a sequence based on a given scoring matrix, such as BLOSUM 62. Our complexity measures also consider the order of amino acids in t...