Wheat germ agglutinin (WGA) precipitates bone type serum alkaline phosphatase (sALP) isoenzyme specifically. The precipitates are composed of the macromolecules of WGA and "bone type sALP" (WGA-ALP complex). In order to use bone type sALP as a marker in polyacrylamide gel electrophoresis (PAGE), a method to separate "bone type sALP" from the "WGA-ALP complex" was established by using N-acetyl-D...

Random-bred Swiss mice were bred selectively for their agglutinin responses to sheep and pigeon erythrocytes to obtain high and low responder lines for those antigens (1). After 20 generations, the two lines differed markedly in their mean agglutinin titers against sheep erythrocytes and were considered established, since the difference in agglutinin response could not be increased by further b...

The sulfated glycosaminoglycans, such as keratan sulfate and chitin sulfate having 3-hydroxy free N-acetyl-beta-D-glucosaminyl residues as constituents, reacted with wheat germ agglutinin and Solanum tuberosum agglutinin by sugar-specific interaction. The glycosaminoglycans showed different inhibitory activities to the hemagglutination reaction of these lectins and keratan sulfate and its modif...

A case of neutropenia in an infant is described, associated with repeated minor infections which responded to treatment with antibiotics. A granulocyte agglutinin was detected in the serum. Following treatment with prednisolone the neutropenia remitted, the antibody disappeared and the infections ceased. Treatment was discontinued after three months and the child remained well five months later...

The results observed with this strain of Treponema pallidum may be stated as follows: 1. Normal human serum did not agglutinate this culture of Treponema pallidum in dilutions of 1:5 or higher; equal parts of treponema culture and normal serum (dilution 1:2) resulted in agglutination in about 50 per cent of the sera. With the strain of Treponema pallidum used in this study specific agglutinatio...

Cold agglutinin disease is a rare autoimmune hemolytic anemia characterized by hemolysis that caused activation of the classic complement pathway. Sutimlimab, humanized monoclonal antibody, selectively targets C1s protein, C1 complex serine protease responsible for activating this

introduction autoimmune haemolytic anemia (aiha) is a complex process characterized by an immune reaction against red blood cell self-antigens. the analysis of specimens, drawn from patients with cold auto-immune hemolytic anemia is a difficult problem for automated hematology analyzer. this paper was written to alert technologists and pathologists to the presence of cold agglutinins and its ef...

Soybean agglutinin (SBA) represents the anti-nutritional molecule in soybean. This agglutinates erythrocytes of several animal species. The specific binding SBA to glycoprotein c...

A patient with evidence of myocardial abnormalities and hemolytic anemia is described, in whom the responsible pathogen appeared to be Mycoplasma pneumoniae (as indicated by a 64-fold rise in complement-fixation titers, and by a change in cold-agglutinin titers from 1:8 to 1:4,096). Both cardiac and hematologic problems occurred during the recovery phase from pneumonia and were associated with ...

A bacterial agglutinin specific for strains of Streptococcus mutans was isolated from human saliva. Physiochemical analyses showed the agglutinin to be a glycoprotein with a molecular weight of 60,000. The agglutinin aggregated four of the eight strains of Streptococcus mutans tested but did not aggregate the strains of Streptococcus salivarius, Streptococcus sanguis, and Streptococcus mitis te...