Here we report on the synthesis and averaged SERS measurements of multi-shell nanomatryoshka SERS tags. By tuning the number of shells or by changing the Raman reporters in different gap layers, their Raman intensities and spectral bands were tunable. These tags show great potential for SERS-based biosensing and bioimaging.

Iodide adsorption and electrochemical negative potential desorption were proposed and compared to obtain clean SERS substrates. The two methods can effectively eliminate the interference of surface impurities in the SERS detection. SERS signals of membranes of living cells with a good reproducibility have been obtained.

Prepared by simple pour and mix chemistry, gold nanosponges (AuNS) are versatile structures for surface-enhanced Raman spectroscopy (SERS). An investigation into the enhancement is performed by relating the nanostructure's morphology to the SERS signal. The potential of the AuNS in SERS-based molecular and biomolecular detection is introduced.

This communication reports, for the first time, the dependence of the SERS intensities under resonant CT conditions (SERS-CT) on the electrode potential. SERS-CT intensities have been estimated from the properties of S(0)-CT(i) transitions ranging between 200-1200 nm of selected [Ag(n)-pyridine](q) and [Ag(n)-pyrazine](q) complexes.

Here, using the (Au/TiO2)-catalyzed reduction of 4-nitrothiophenol as a probe reaction, a catalysis/SERS bifunctional composite fabricated by uniformly dispersing catalysis-active Au nanoclusters (∼2 nm) on a SERS-active TiO2 photonic microarray was successfully applied to the non-plasmonic SERS self-monitoring of a catalytic reaction for the first time, which is superiorly sensitive and interf...

Somatosensory evoked responses (SERs) to mechanical stimulation were recorded in 5 patients with occupational vibration disease and 10 grader drivers, and the results were compared with those obtained from 48 normal subjects. SERs were recorded at room temperature of 20-23 degrees C and after immersing the hand in hot (40 degrees C) or cold (10 degrees C) water for 5 minutes. SERs were also rec...

Simplicity and low cost has positioned inkjet paper- and fabric-based 3D substrates as two of the most commonly used surface-enhanced Raman spectroscopy (SERS) platforms for the detection and the identification of chemical and biological analytes down to the nanogram and femtogram levels. The relationship between far-field and near-field properties of these 3D SERS platforms remains poorly unde...

OBJECTIVES/HYPOTHESIS Assess the reliability of a Sleep Endoscopy Rating Scale (SERS) and its relationship with pediatric obstructive sleep apnea (OSA) severity. STUDY DESIGN Retrospective case series of pediatric patients who underwent drug-induced sleep endoscopy (DISE) at the time of surgery for OSA from January 1, 2013 to May 1, 2014. METHODS Three blinded otolaryngologists scored obstr...

Dye conjugation is a common strategy improving the surface enhanced Raman detection sensitivity of biomolecules. Reported is a proof-of-concept study of a novel surface enhanced Raman spectroscopic tagging strategy termed as acid-cleavable SERS tag (ACST) method. Using Rhodamine B as the starting material, we prepared the first ACST prototype that consisted of, from the distal end, a SERS tag m...

Monitoring enzyme kinetics is an important aspect of biochemistry and is essential when studying metabolism. In this study we demonstrate that succinate dehydrogenase activity of mitochondria can be analyzed quantitatively by surface enhanced Raman scattering (SERS). We used the artificial electron acceptor reporter molecule 2,6-dichlorophenolindophenol (DCPIP) that when oxidized is SERS active...