Abstract Indirect agonism has been invoked as part of the mechanism antipsychotic action at dopamine D 2/3 receptors, and more recently a salient neuropharmacological aspect serotonin 5‐HT 2A drug pimavanserin (Pim). We now comment on an article in this volume showing that Pim treatment attenuates deposition Aβ protein brain transgenic Alzheimer's disease model mice. may interfere with by shift...

Progressive multifocal leukoencephalopathy (PML) is a severe encephalic demyelinating disease associated with JC virus (JCV) reactivation that occurs mostly in patients with immune disorders. Patients affected by sarcoidosis are at risk for developing PML both for leukocyte dysfunction and for receiving immunosuppressive medications: delayed diagnosis and high-dose corticosteroids are associate...

Although 5HT(2A) receptors mediate contractions of normal arteries to serotonin (5HT), in some cardiovascular diseases, other receptor subtypes contribute to the marked increase in serotonin contractions. We hypothesized that enhanced contractions of arteries from diabetics to 5HT are mediated by an increased contribution from multiple 5HT receptor subtypes. We compared responses to selective 5...

Suicide is a complex and multifaceted public health issue that has been intensively studied to identify its contributing factors. Serotonin, neurotransmitter essential for affective regulation mood control, linked suicidal propensity. Understanding the relative contribution of serotonin’s genetic versus non-genetic influences development effective preventive measures, given etiology suicide inv...

EditorÐWe congratulate the authors on an excellent review of aspects of the pathophysiology of malignant hyperthermia (MH). They have explained the postulated role of serotonin in MH, in particular the role of peripheral 5-HT2 receptors, based on in vitro and in vivo animal work. There are important parallels between serotonin toxicity and MH, and this review adds to our understanding of the ro...

If it’s true that if you can remember the 1960s, then you weren’t there, it is likely in large part because of delta-9-tetrahydrocannabinol (THC), the major psychoactive ingredient in marijuana, one of whose effects is memory impairment. While recreational marijuana users may seek the full range of its effects, broad medical use of THC—including for pain, nausea, and anxiety—is hindered by them...

Diabetic neuropathic pain, an important micro vascular complication in diabetes mellitus, has been recognized as one of the most difficult types of pain to treat. Lack of understanding of etiology involved, inadequate relief, development of tolerance and potential toxicity of classical anti-nociceptive agents warrants the investigation of newer agents to relieve this pain. The aim of the presen...

Serotonin (5-HT) is an indirect modulator of the electric organ discharge (EOD) in the weakly electric gymnotiform fish, Brachyhypopomus pinnicaudatus. Injections of 5-HT enhance EOD waveform "masculinity", increasing both waveform amplitude and the duration of the second phase. This study investigated the pharmacological identity of 5-HT receptors that regulate the electric waveform and their ...

The LPHN3 gene has been associated with both attention deficit-hyperactivity disorder (ADHD) and addiction, suggesting that it may play a role in the etiology of these disorders. Unfortunately, almost nothing is known about the normal functions of this gene, which has hampered understanding of its potential pathogenic role. To begin to characterize such normal functions, we utilized a gene-trap...

Serotonin(1A) receptors are important neurotransmitter receptors and belong to the superfamily of G-protein coupled receptors (GPCRs). Although it is an important drug target, the crystal structure of the serotonin(1A) receptor has not been solved yet. Earlier homology models of the serotonin(1A) receptor were generated using rhodopsin as a template. We have used two recent crystal structures o...