PURPOSE Werner syndrome is an autosomal recessive disease of premature aging caused by a polymorphic C1367T mutation in the Werner (WRN) gene. Although there are differences between the pathobiology of normal aging and the phenotype of Werner syndrome, the clinical age-related changes are similar. The aim of the study was to investigate the incidence of the C1367T (rs1346044) polymorphism in pa...

Objective: To report the prevalence of pseudo exfoliation in association with Cataract and other ocular diseases at a tertiary eye care centre in Sindh, Pakistan. Methodology: This was a hospital based study at Liaquat University Eye hospital, Hyderabad Sindh, Pakistan conducted from July, 2005 to November, 2006. A total of 1450 subjects of more than fifty years with senile cataract were regist...

The epidemiology of cataract has attracted little attention. The definition of cataract is difficult enough to make surveys of its prevalence in populations of doubtful value. One partial solution is to consider only cataract of a degree sufficient to be operated upon. Fuchs (1960) has published figures showing a very wide variation in the proportions of patients with cataract admitted to vario...

OBJECTIVE To identify popular beliefs regarding the treatment of senile cataract in patients enrolled in the community health programs on eye rehabilitation. METHODS A cross-sectional survey was carried out using an interview questionnaire that was applied to 776 subjects drawn from a non-probabilistic sample in five cities of the state of São Paulo. The sample was made up of 47.2% males and ...

BACKGROUND It is generally stated that opacities of the ocular media, including senile cataract, have little effect on the electrical responses of the retina. However, lower amplitudes and longer implicit times are sometimes observed in electroretinograms (ERGs) of patients with mature cataract. METHODS Single flash ERGs of mature cataractous eyes with decimal visual acuity less than 0.1 were...

Cataract is characterized partial or complete loss of transparency of the lens that leads to loss of vision. Globally, cataract associated blindness is a major cause of morbidity in developing countries. The cataractogenesis is affected by a number of factors with redox imbalance at the top of list. This imbalance results either from an increased generation of free radicals and/or decreased pro...

An account is given of asymptomatic diabetes mellitus. To determine the incidence in 200 patients with senile cataract 3 tests are described, namely, a modified standard glucose tolerance test, a provocative steroid glucose tolerance test, and a standard glucose tolerance test. Known diabetics and patients with a fasting blood glucose in excess of 5.5 mmol/l or glycosuria were excluded. Eighty-...

Aging is a fundamental biologic phenomenon that occurs even in the absence of disease, each cell having a genetically programmed lifespan. Tissues that do not undergo mitotic division to replace this cell fallout, such as the central nervous system and the retina, have a high incidence of aging manifestations, particularly after 75 years of age. As the lens ages, it increases in weight and thic...

Cataract.?I enclose herewith a table (Table I) showing the total number of operations for senile cataract undertaken at the three in-door dispensaries in this district, with the number successful and percentage of successes taken from the records for the year 1891-1900. As regards this table there is little to say except that possibly more difficult cases were attempted at the Head-Quarter disp...

A study was made of records of patients who have had at least 1 senile cataract removed and for whom refraction records were available. The risk of a cataract occurring was determined as a function of precataractous refraction. Emmetropia was found to provide a sharp borderline between the low risk (about 1:1000) of hypermetropes and an increasing risk (about 1:100) for moderate myopes for pati...