The nature of the encephalopathic agent present in monkey bone marrow has been investigated. It is readily soluble at a pH of 7.4, as well as at the low pH of 2.0 and 3.0. The point of minimal solubility is pH 4.2. Heat inactivation is produced by a temperature of 75 degrees C., acting for 15 minutes. The agent is digested by pepsin. It exhibits a slight degree of sedimentation with the air-dri...

Poor bioavailability of drugs associated with their poor solubility limits the clinical effectiveness of almost 40% of the newly discovered drug moieties. Low solubility, coupled with a high log p value, high melting point and high dose necessitates exploration of alternative formulation strategies for such drugs. One such novel approach is formulation of the drugs as "Nanocrystals". Nanocrysta...

Alasan, a high-molecular-weight bioemulsifier complex of an anionic polysaccharide and proteins that is produced by Acinetobacter radioresistens KA53 (S. Navon-Venezia, Z. Zosim, A. Gottlieb, R. Legmann, S. Carmeli, E. Z. Ron, and E. Rosenberg, Appl. Environ. Microbiol. 61:3240-3244, 1995), enhanced the aqueous solubility and biodegradation rates of polyaromatic hydrocarbons (PAHs). In the pres...

The aim of the present study was to improve solubility and dissolution of the poorly aqueous soluble drug, etoricoxib by solvent evaporation technique using various sugar carriers, such as lactose, sucrose, and mannitol. Etoricoxib solid dispersions and their respective physical mixtures using lactose, sucrose, and mannitol were prepared in different ratios by solvent evaporation technique. The...

The solubility of oxygen in n-hexane and in n-perfluorohexane was determined experimentally and calculated by computer simulation. A precision apparatus based on a saturation method at constant pressure was used to measure the solubility at temperatures from 288 to 313 K and close to atmospheric pressure. Henry’s law coefficients, H2,1(T,p sat 1 ), were obtained from the experimental data and t...

the simultaneous flow of oil and water in porous media is described by relative permeability curves, mainly derived from laboratory experiments. relative permeability is of paramount importance in predicting reservoir production performance and drive mechanisms and its value depends largely on the volume fraction of fluids present in the test samples. nowadays x-ray scanners are one of the most...

• Mathematical model of drug release from drug-excipient granules. Developed can account for radial variations in porosity and content. Model accounts internal diffusion solubility-limited extraction granule. Solubility-limited give rise to a range moving boundary value problems. A reduced-order is presented the case which initial load greatly exceeds solubility Understanding pharmaceutical gra...

The presence of small vesicles composed of phospholipid and cholesterol has recently been demonstrated in super-saturated model and in dilute native human biles by several groups using differing methods. Among compositional factors shown to favor spontaneous vesicle formation and prolong the cholesterol monohydrate nucleation time in model bile systems are dilution, a raised cholesterol saturat...

chitosan with excellent biodegradable and biocompatible characteristics has received attention as an oral drug delivery vehicle for controlled-release formulations. in this study an enteric-coated capsule containing theophylline-chitosan beads based on 23 factorial designs was prepared as a colon drug delivery system. the theophylline-chitosan gel beads were formulated by adding the drug-contai...

Etodolac (ETD) is a non-steroidal anti-inflammatory drug (NSAID) given in rheumatoid arthritis treatment. As it comes under BCS class II hence exhibits low water solubility. Also, its dissolution rate-limited oral absorption results delayed onset of action. The Novel approach the solubility enhancement field; crystal engineering was preferred to prepare pharmaceutical cocrystals etodolac with G...