BACKGROUND Most preclinical studies are carried out on mice. For internal dose assessment of a mouse, specific absorbed fraction (SAF) values play an important role. In most studies, SAF values are estimated using older standard human organ compositions and values for limited source target pairs. OBJECTIVE SAF values for monoenergetic photons of energies 15, 50, 100, 500, 1000 and 4000 keV we...

OBJECTIVES The aim of the present study was to investigate immunotoxic effect of safranal (SAF), a main component of Crocus sativus essential oil, using Balb/c mice. MATERIALS AND METHODS SAF was administered intraperitoneally at doses of 0.1, 0.5 and 1 ml/kg for 3 weeks. Hystopathological examination of spleen and bone marrow, cellularity of spleen, delayed type of hypersensitivity (DTH) res...

Segregation of chromosomes during cell division requires correct formation of mitotic spindles. Here, we show that a scaffold attachment factor A (SAF-A), also known as heterogeneous nuclear ribonucleoprotein-U, contributes to the attachment of spindle microtubules (MTs) to kinetochores and spindle organization. During mitosis, SAF-A was localized at the spindles, spindle midzone and cytoplasmi...

Abstract The hydraulic performance of stilling basins is affected by their size and geometry. Taunsa Barrage, Pakistan, was constructed in 1958 remodelled 2008. In remodelling, baffle friction blocks were replaced chute dentated sill. After sounding, probing data during 2010–2014 revealed that flexible apron front some bays washed away. This study quantified parameters such as free surface, flo...

The violent fluctuation of hydrodynamic pressure in stilling basins is an important factor threatening the safety bottom plates basins, and plays role safe operation basins. In order to deeply understand fluctuating characteristics signal a basin plate processed by Hilbert-Huang transform method through hydraulic model test. this paper, three decomposition methods are used decompose pulsating s...

Introduction: The forced hydraulic jump characteristics were studied numerically using Flow-3D software. Rectangular and semi-cylindrical shape slices used as obstacles with different arrangements in the stilling basin to dissipate excess kinetic energy. Methods: Each type was tested under five values of discharges (60, 80, 100, 120, 160 l s -1 ). numerical results showed that act good energy d...

BACKGROUND The metabolic syndrome (MetS) comprises several cardiometabolic risk factors associated with increased risk for both type 2 diabetes and cardiovascular disease. Skin autofluorescence (SAF), a non-invasive biomarker of advanced glycation end products accumulation, is associated with cardiovascular complications in subjects with diabetes. The aim of the present study was to examine the...

BACKGROUND We aimed to analyze the relationships between skin autofluorescence (SAF) and incident macrovascular events and renal impairment after 4 years of follow-up in patients with type 1 diabetes (T1D). METHODS Two hundred and forty-three patients (51.2 ± 16.7 years old) with T1D participated. SAF was measured by AGE-Reader-TM at inclusion. Macrovascular events (MVE), estimated glomerular...

Skin auto fluorescence (SAF) is used as a proxy for the accumulation of advanced glycation end products (AGEs) and has been proposed to stratify patients into cardiovascular disease (CVD) and diabetes mellitus (DM) risk groups. This study evaluates the effects of seven different ethnicities (Arab, Central-East African, Eastern Mediterranean, European, North African, South Asian and Southeast As...