background: metabolic syndrome (mets) is a prevalent disorder in pediatric age groups, described by a combination of genetic and environmental factors. sterol regulatory element‑binding transcription factor 1 (srebf‑1) induces the expression of a family of genes involved in fatty acid synthesis. moreover, dysregulation of mir‑33b, which is located within the intron 17 of the srebf‑1 gene, disru...

patients and methods in this cross-sectional study, peripheral mononuclear cells (pbmcs) were isolated from peripheral blood of 29 patients with newly diagnosed pulmonary tb and 19 patients with positive tuberculin skin test. the pbmcs were activated with ppd for 72 hours. activated cells were harvested, rna was extracted and cdna was synthesized. a real-time taqman method was designed and opti...

background: polycystic ovary syndrome (pcos) is one of the most common endocrine women’s disorders in reproductive age. hyperandrogenism has a critical role in the etiology of pcos and it can cause fault in steroidogenesis process. during steroidogenesis, steroidogenic acute regulatory protein (star) seems to increase the delivery of cholesterol through mitochondrial membrane. therefore, polymo...

objective: hepatitis c virus (hcv) is one of the most relevant persistent infections afflicting the human population. control of viral replication in hcv infection has been associated with the cellular component of the host immune response. several mechanisms have been proposed to explain this abnormal immune response, among them an altered activity of regulatory t cells (tregs) being the most ...

although there are substantial experimental, epidemiological and clinical evidences that high doses of ionizing radiation cause cancer and other detrimental biological effects, the health effects of human exposure to chronic low dose radiation exposures are still poorly known. people in some areas around the world live in dwellings with radiation and radon levels as much as more than 200 times ...

background pharmacovigilance (pv) data are crucial for ensuring safety and effectiveness of medicines after drugs have been granted marketing approval. this paper describes the pv systems of india, uganda and south africa based on literature and key informant (ki) interviews and compares them with the world health organization’s (who’s) minimum pv requirements for a functional national pv syste...

background according to world health organization (who) estimation, more than half of all pharmaceutical products are inappropriately prescribed, distributed, and sold and more than half of all patients use the medicines prescribed for them incorrectly. as more than 40% of therapeutic costs are pharmaceutical costs, this implies a significant waste of health resources in the world. objectives t...

the internet has transformed the manner of conducting commercial transactions and has created regulatory gaps. these regulatory gaps may impact the effective development of electronic commerce. attempts are being made to regulate electronic contracts both at the national and international level. the present research analyses these attempts, in particular the electronic transaction legislation o...

Background and objectives: Curcumin as a medicinal substance has shown effective in different kinds of diseases especially cancer. To understand its underlying mechanism, molecular complementary study of differentially expressed microRNAs (DEMs) could assist. In this view, regulatory network analysis of DEMs of melanoma cancer treated with curcumin versus the untreated male <em...