Red blood cells (erythrocytes) are normally produced only in the bone marrow of adults, but during embryonic and fetal life erythropoiesis occurs in the liver, and during the second to the fifth month of fetal life it occurs in the spleen.' From the fifth month after gestation marrow production increases gradually, having begun to take over from the liver during late fetal and early neonatal li...

Aqueous glutaraldehyde has been polymerized under alkaline conditions in the presence of a surfactant to yield microspheres of varied diameters. Microbeads of a nominal 300 nm diameter, made fluorescent via fluoresceinisothiocyanate, were used as a carrier of rabbit anti-human red blood cell antibodies. Specific labeling of the human red blood cells as well as diagnostic use of these fluor...

precursors and progenitors to increase production of fetal hemoglobin. J Clin Invest 75: 547-557, 1985 51. Rosa RM, Bierer BE, Thomas R, Jeffrey BS, Stoff JS, Kruskall M, Robinson S, Bunn HF, Epstein FH: A study of induced hyponatremia in the prevention and treatment of sickle-cell crisis. New Eng J Med303: 1138-1143, 1980 52. Leary M, Abramson N: Induced hyponatremia for sickle-cell crisis. Ne...

Disorders of the erythrocyte membrane, including hereditary spherocytosis, hereditary elliptocytosis, hereditary pyropoikilocytosis, and hereditary stomatocytosis, comprise an important group of inherited hemolytic anemias. These syndromes are characterized by marked clinical and laboratory heterogeneity. Recent molecular studies have revealed that there is also significant genetic heterogeneit...

precursors and progenitors to increase production of fetal hemoglobin. J Clin Invest 75: 547-557, 1985 51. Rosa RM, Bierer BE, Thomas R, Jeffrey BS, Stoff JS, Kruskall M, Robinson S, Bunn HF, Epstein FH: A study of induced hyponatremia in the prevention and treatment of sickle-cell crisis. New Eng J Med303: 1138-1143, 1980 52. Leary M, Abramson N: Induced hyponatremia for sickle-cell crisis. Ne...

Diphosphoglycerate mutase (DPGM) was purified to homogeneity from human erythrocytes. The enzyme and Freund adjuvant were infected into chickens and yielded a monospecific precipitating antibody. Radial immunodiffusion with this antibody was used to measure the amount of DPGM in hemolysates from human adult and cord red cells. Dog, rabbit, rat, chicken, and goat red cells all had DPGM during th...

Mutations leading to red cell enzyme deficiencies can be associated with diverse phenotypes that range from hemolytic anemia, methemoglobinemia, polycythemia, and neurological and developmental abnormalities. While most of these mutations occur sporadically, some such as common glucose-6-phosphate dehydrogenase (G6PD) mutants are endemic and rarely cause disease. Common G6PD mutants likely reac...