A 73-year-old female patient was referred to our department because of gouty arthritis in the right first toe. The patient suffered from progressive renal failure because of pauci-immune necrotising glomerulonephritis. As severe hyperuricaemia would further worsen progredient renal insufficiency and therapy with allopurinol was contraindicated because of renal insufficiency and previous pancyto...

A method for rapid morphologic phenotyping is demonstrated by using magnetic resonance microscopy. Whole fixed C57BL/6J mice were imaged at 110-microm isotropic resolution; limited volumes of the intact specimen, at 50-microm isotropic resolution; and isolated organs, at 25-microm isotropic resolution. The three-dimensional imaging technique was applied to uricase knockout mice to demonstrate t...

TLS (tumor lysis syndrome) is a serious consequence of haematologic malignancies and their treatment. The condition defined by laboratory abnormalities alone (laboratory TLS) or in conjunction with clinical consequences such as renal failure, seizures, arrhythmias (clinical TLS). Clinical risk factor for increased morbidity death cancer patients, although it may be avoided. As result, accurate ...

etary riboflavin, neither were they related to EGRAC or plasma ribofla-vin. This supports the use of EGRAC, and, to a lesser extent, plasma ribo-flavin, as a marker of riboflavin status that reflects dietary intake. We do not agree with the suggestion that the improvement in folate status in the folate-rich diet should have compromised riboflavin status, as it did in the folic acid supplemen-ta...