BackgroundAtopic dermatitis (AD) is a chronic inflammatory skin disease. Interleukin (IL) 13 type 2 cytokine that key to the inflammation underlying AD. Tralokinumab first-in-class, fully human, monoclonal antibody specifically binds with high affinity IL-13, neutralizing it in Immunomodulatory treatments may impair vaccine-induced immune responses.ObjectiveAssess responses standard vaccines ad...

Background In light of solid data regarding the extent of the placebo response as well as the rigorous arguments in favor of the randomized, placebo-controlled clinical trial, placebo analgesia has widely been tested and documented as one of the most robust placebo effects. Newly developed brain imaging tools such as functional magnetic resonance imaging (fMRI) have provided systematic evidence...

METHODS: Collagenase derived from Clostridium Histolyticum was used in a randomized, double-blinded, placebo controlled study on a total of 19 healthy subjects, each with two biopsy-proven lipomas of similar size (one to receive drug and one to receive placebo) at two independent investigational centers (Office of Z. Gerut and Dept. of Plastic Surgery Vanderbilt Univ. Med Ctr.). An independent ...

A 12=week, multicenter, double-blind, randomized, placebo-controlled trial of imazodan, a type Ill phosphodiisterase inhibitor, was conducted in 147 patients with congestive heart failure to determine clinical efficacy and safety. Patients were randomized to placebo or 2,s or 10 mg of imazodan administered twice daily. Patients were maintained on their standard therapy including diuretics, digo...

Background. Erythropoietin (EPO) is a neuroprotective agent utilized in stroke patients. This pilot study represents the first randomized trial of EPO in traumatic brain injury (TBI) patients. Methods. Adult, blunt trauma patients with evidence of TBI were randomized to EPO or placebo within 6 hours of injury. Baseline and daily serum S-100B and Neuron Specific Enolase (NSE) levels were measure...

BACKGROUND Macrolides have antimicrobial and anti-inflammatory properties that may be useful in the treatment of chronic asthma. METHODS We performed a randomized, placebo-controlled, double-blinded effectiveness trial of 12 weekly doses of adjunctive azithromycin, with follow-up to 1 year after randomization, in adults with persistent asthma. Measurements included overall asthma symptoms, as...

introduction: pain in the achilles tendon during loading is a very common condition. conservative treatments, such as low level laser therapy (lllt) have been reported to give varying results. recently, a new laser treatment technique, high power laser treatment (hplt) (swiss dynalaser®), was introduced in scandinavia, but has not, to our knowledge, been systematically tested before. the object...

BACKGROUND The beneficial effects of testosterone treatment (TT) are debated. METHODS Double-blinded, placebo-controlled study of six months TT (gel) in 54 men aged 60-78 with bioavailable testosterone (BioT) <7.3 nmol/L and waist >94 cm randomized to TT (50-100 mg/day, n = 20), placebo (n = 18), or strength training (ST) (n = 16) for 24 weeks. Moreover, the ST group was randomized to TT (n =...

In randomized controlled trials, medication side effects may lead to beliefs that one is receiving the active intervention and enhance active treatment responses, thereby increasing drug-placebo differences. We tested these hypotheses with an experimental double-blind randomized controlled trial of a nonsteroidal anti-inflammatory drug with and without the addition of atropine to induce side ef...

BACKGROUND It is widely believed that in randomized controlled trials of antidepressants the difference between drug and placebo response rates is rather small (around 20%), leading to a common perception that antidepressants have limited efficacy. AIM The aim of the present paper was to present an alternative calculation and interpretation of antidepressant-placebo difference in the treatmen...