Background\Aim: Quadruple daily administration of proton-pump inhibitor (PPI) therapy achieves potent acid inhibition, and combined with amoxicillin, with its pharmacodynamic and pharmacokinetic characteristics, may be efficient for Helicobacter pylori eradication. We compared the efficacy of two optimized high-dose dual therapies with a bismuth-containing quadruple regimen for treating H. pylo...

BACKGROUND Scant data exist on the normal range of serum gastrin in infants. In phase I and III trials of rabeprazole in gastroesophageal reflux disease, we studied serum gastrin levels in infants 1 to 11 months old, and assessed normal ranges and the effect of acid-suppressive drugs. METHODS Overall, 349 treatment-naïve or treatment-experienced (previously exposed to proton pump inhibitors a...

Currently, peptic ulcer disease remains the most common of digestive system. Ulcerative bleeding is a terrible complication. The main condition for successful conservative treatment gastrointestinal that occurs against background acid-dependent diseases adequate acid-reducing therapy. We conducted study comparing different modes administration proton pump blockers. To this end, three groups wer...

I n t e r v e n t i o n 70 patients each were allocated to 4 treatments: 1) a 10-day course of once-daily levofloxacin, 500 mg; twice-daily amoxicillin, 1 g; twice-daily rabeprazole, 20 mg (LAR); 2) a 10-day course of once-daily levofloxacin, 500 mg; twice-daily tinidazole, 500 mg; and twice-daily rabeprazole, 20 mg (LTR); 3) a 7-day course of 4 times daily tetracycline, 500 mg; 3 times daily m...

Background. The aim of this study was to compare the effect of high-dose oral rabeprazole versus high-dose IV PPI on rebleeding after endoscopic treatment of bleeding peptic ulcers. Methods. This was a two-center, prospective, randomized, controlled trial. Patients with a high-risk bleeding peptic ulcer had endoscopic hemostasis and were randomly assigned to the high-dose oral rabeprazole group...

BACKGROUND Levofloxacin has been shown to be effective in Helicobacter pylori eradication. Two 10-day levofloxacin-based triple therapies were compared with standard 7- and 14-day quadruple regimens in second-line treatment. METHODS Two hundred and eighty consecutive patients who failed to respond to standard triple therapy (clarithromycin, amoxicillin, rabeprazole) were randomly assigned to ...

As inhibitors of organic cation transporters (OCTs), proton pump inhibitors (PPIs) may affect the plasma levels of metformin, an OCT substrate. We investigated the effects of two PPIs, pantoprazole and rabeprazole, on metformin pharmacokinetics and glucose levels in healthy subjects. In this open, randomized, six-sequence, three-period crossover study, 24 participants were administered metformi...

Treatments with bismuth-containing quadruple therapy (QT), sequential therapy (ST), or concomitant therapy (CT) have been proposed as empirical first-line regimens for Helicobacter pylori. We compared the efficacy and tolerability of 10 days bismuth-containing quadruple QT, 10 days ST, and 10 days CT with as first-line treatments for H. pylori in a randomized crossover study. The subjects were ...