The incidence of lymphoma and myeloma is increased in rheumatoid arthritis (RA), though the reasons for this are incompletely understood. The predictive value of monoclonal gammopathy in RA for the later development of lymphoproliferative malignancy was assessed. A serum paraprotein was discovered in 23 patients (14 female) with a median age of 58 years and a median duration of RA of six years....

Single progesterone receptor positive (PgRþ), especially in form of ER /PgRþ/HER2 , is a nonnegligible phenomenon. Little is known about the characteristics and the role of single PgR positive in this phenotype. Therefore, we explore the significance of single PgR positivity by comparing ER /PgRþ/HER2 breast cancers with triple negative breast cancers (TNBCs). Three thousand nine hundred sixty-...

Low tissue oxygen concentration has been shown to be important in the response of human tumors to radiation therapy, chemotherapy and other treatment modalities. Hypoxia is also known to be a prognostic indicator, as hypoxic human tumors are more biologically aggressive and are more likely to recur locally and metastasize. Herein, we discuss and summarize the various methods under investigation...

The practicing physician, despite mass chest x-ray surveys and similar programs, must still remain the most important single factor in tuberculosis case finding. Early case finding and treatment are the major tenets of effective tuberculosis control, as they are in any communicable disease, and have been practiced most diligently in many areas. The presence of parenchymal pulmonary lesions by x...

QRS duration and morphology, evaluated via a standard 12-lead electrocardiogram (ECG), represent an opportunity to derive useful prognostic information regarding the risk of subsequent cardiac events or therapeutic outcomes. Prolonged QRS duration, and the presence of intraventricular conduction abnormalities, usually indicate the presence of changes in the myocardium due to underlying heart di...

involvement of genetic alterations in breast cancer, one of the most common types of female malignancie, has been well documented . among the possible alterations, mutations in several genes including p53 as an important prognostic factor, have been extensively studied. mutated p5 protein has longer half-life than the wild type protein that is detectable by immunohistochemistry (ihc). our study...