This study aimed to develop an intravesical delivery system of gemcitabine HCl for superficial bladder cancer in order to provide a controlled release profile, to prolong the residence time, and to avoid drug elimination via urination. For this aim, bioadhesive nanoparticles were prepared with thiolated chitosan (chitosan-thioglycolic acid conjugate) and were dispersed in bioadhesive chitosan g...

OBJECTIVE Corneal ulcers are commonly encountered in pinnipeds. Prolonged oral antibiotics and topical ophthalmic solutions may not be practical to administer, and novel treatment techniques are desired. Thermodynamic gels are a potential solution because they hold antimicrobials at the site of injection, slowly releasing drug. This study investigated the clinical efficacy of antibiotic-impregn...

BACKGROUND Safe and effective myocardial gene transfer remains elusive. Heterogeneous ventricular gene delivery has been achieved in small mammals but generally with methods not readily transferable to the clinic. Atrium-specific gene transfer has not yet been reported. We hypothesized that homogeneous atrial gene transfer could be achieved by direct application of adenoviral vectors to the epi...

Meloxicam is included in the class II Biopharmaceutical Classification System (BCS). This drug has low solubility and high permeability. The one of factors that affect dissolution rate drug. One effort to increase meloxicam by forming a solid dispersion system made using melting method. addition PEG 6000 poloxamer 188 carriers determine aims meloxicam. purpose this study characterize with matri...

Objective: The article presents the results of studying parameters in situ systems based on poloxamers. Methods: Natural, synthetic and semi-synthetic polymers were considered as additional gel-forming agents. above-mentioned agents cellulose derivatives, well rare-cross-linked acrylic polymers, alginic acid salts, xanthan gum. gelation temperature was visually recorded during gradual heating. ...

Climate change modulates the effects of solar UV radiation on biogeochemical cycles in terrestrial and aquatic ecosystems, particularly for carbon cycling, resulting in UV-mediated positive or negative feedbacks on climate. Possible positive feedbacks discussed in this assessment include: (i) enhanced UVinduced mineralisation of above ground litter due to aridification; (ii) enhanced UV-induced...

at least among some urban populations.7 A third hypothesis is based on the stages of an adolescent’s acquisition of lesbian or bisexual identity. “Heterosexual immersion” may be one strategy for responding to the identity confusion stage of development: “Some adolescents establish heterosexual involvements in hopes of ‘curing’ themselves of their homosexual interests....In some cases, an adoles...