A series of mono-cationic dinuclear have been synthesized using ((pyridi picolinamide (L2) ligands: [(h6-arene C5Me5)2M2(m-L1)Cl3]þ (M 1⁄4 Rh, 4 p-PrC6H4Me, 7; C6Me6, 8), [(h-C5Me isolated as their hexafluorophosphate IR spectroscopy. The solid state struc ray crystallographic studies. Interestin nitrogen atoms whereas the second terminal chloride ligands. Fascinatin both ruthenium centers havi...

The human tyrosinase gene TYR is a multifunctional reporter gene with potential use in photoacoustic imaging (PAI), positron emission tomography (PET), and magnetic resonance imaging (MRI). We sought to establish and evaluate a reporter gene system using TYR under the control of the Tet-on gene expression system (gene expression induced by doxycycline [Dox]) as a multimodality imaging agent. We...

The title compound, [Cu(C12H8N3O2)(N3)(H2O)], was formed by the air oxidation of 2-(amino-meth-yl)pyridine in 95% ethanol in the presence of copper(II) nitrate and sodium azide with condensation of the resulting picolinamide mol-ecules to generate the imide moiety. The Cu(II) ion has a square-pyramidal coordination sphere, the basal plane being occupied by four N atoms [two pyridine (py) N atom...

BACKGROUND The development of novel highly efficacious fungicides that lack cross-resistance is extremely desirable. Fenpicoxamid (Inatreq™ active) possesses these characteristics and is a member of a novel picolinamide class of fungicides derived from the antifungal natural product UK-2A. RESULTS Fenpicoxamid strongly inhibited in vitro growth of several ascomycete fungi, including Zymosepto...

Solid state reactions, induced by mechanical energy, liquid-assisted grinding (LAG) and ball milling, have become established methods for the preparation of pharmaceutical cocrystals. Examination of the mechanochemical reaction pathways reveal the existence of different intermediate phases of variable crystallinity. Poor physicochemical properties (solubility and permeability) of active pharmac...