Nowadays the application of nanotechnology in different biomedical fields such as drug delivery is increasing due to its unique advantages. With this in mind, it is widely believed that nanogels as the nanometer-sized networked polymeric particles have a considerable impact on drug delivery systems as biocompatible nanocarriers due to their unique characteristics such as high loading capacity, ...

Nanotechnology has emerged as a possible solution to improve phytochemicals’ limitations. The objective of the present study was encapsulate beetroot extract (BR Ext) within chitosan (CS)-based nanogel (NG) designed via ionic crosslinking with tripolyphosphate (TPP) for betanin (Bet) delivery, mainly in ophthalmic environment. BR Ext is rich according thin layer chromatography (TLC), UV-visible...

A strategy involving free radical copolymerization of a difunctional oligomer and a small-molecule crosslinker to give sub-10 nm nanogels is proposed. These nanogels can adapt to surrounding temperatures and regulate the release of a preloaded model anticancer drug 5-fluorouracil.

Poly(vinyl acetate-co-vinyl alcohol) (PVA), well-known as emulsion stabilizers, are obtained by partial hydrolysis of poly(vinyl acetate) (PVAc). Their thermal cloud point fractionation was performed in aqueous medium between 40 and 75 °C. This fractionation was carried out in order to get an insight in the partition of the initially present nanogels in the different fractions. All the fraction...

The paper demonstrates a class of multifunctional core-shell hybrid nanogels with fluorescent and magnetic properties, which have been successfully developed for simultaneous optical temperature sensing, tumor cell imaging and magnetic/NIR-thermally responsive drug carriers. The as-synthesized hybrid nanogels were designed by coating bifunctional nanoparticles (BFNPs, fluorescent carbon dots em...

BACKGROUND The concept of closed-loop control of glucose, in which continuous glucose sensing is coupled to a fully automated insulin delivery device, without human input, has been an attractive idea for diabetes management. This study presents a new class of hybrid nanogels that can integrate glucose sensing and glucose-responsive insulin release into a single nano-object. METHODS Zinc oxide...

We have developed sparsely cross-linked "nanogels", sub-colloidal polymer structures composed of covalently linked, linear polyacrylamide chains, as novel DNA sequencing matrices for capillary electrophoresis. The presence of covalent cross-links affords nanogel matrices with enhanced network stability relative to standard, linear polyacrylamide (LPA), improving the separation of large DNA frag...