Chitin-silica represents a potentially useful superdisintegrant in many pharmaceutical applications. The "intimate" association between chitin and silica, without evidence of chemical reaction, creates an insoluble, hydrophilic, highly absorbent inert material. The new superdisintegrant is characterized by superiority in water uptake and water penetration, with no gelling hindrance effects, as ...

In this study, simple, fast and reliable cyclic voltammetry (CV), linear sweep voltammetry (LSV), square wave voltammetry (SWV) and differential pulse voltammetry (DPV) methods were developed and validated for determination of bosentan in pharmaceutical preparations. The proposed methods were based on electrochemical oxidation of bosentan at platinum electrode in acetonitrile solution containin...

In the present work simple, precise, specific, accurate and cost effective UV spectrophotometric method has been developed for the determination of Mirabegron in pure and pharmaceutical formulation. The wavelength of the Mirabegron detection was 251 nm using methanol as a solvent and obeys Beer’s law in the concentration range of 0.2 – 1.2 μg /mL with a correlation coefficient of 0.9991. Relati...

In this study, simple, fast and reliable cyclic voltammetry, linear sweep voltammetry, square wave voltammetry and differential pulse voltammetry methods were developed and validated for determination of etodolac in pharmaceutical preparations. The proposed methods were based on electrochemical oxidation of etodolac at platinum electrode in acetonitrile solution containing 0.1 M lithium perchlo...

According to Process Analytical Technology perspective, drug product quality should be ensured by manufacturing process design. Initial step of the process analysis is investigation of critical process parameters (CPPs). It is generally accepted to type the CPPs based on project team knowledge and experience [5]. This paper describes the use of Design of Experiments tool for selection of the CP...

Compaction simulators are designed as machines which can provide an in-depth analysis of the powder compaction process. Characterization compression and process, well material characterization, play important role in formulation manufacturing process design development, creating a strong knowledge basis for scale-up tablet troubleshooting further stages product lifecycle. Although to simulate o...

Binders are added in tablet formulation to increase the inter-particulate bonding strength with tablet. promoting ingredient a mix together.The main aim of this work formulate new excipient that is fragrant manjakfor future use as binding agent formulation, also check their effect on concentration and disintegration time. Binder employed impact cohesiveness granules. Natural binder like differe...

Background: Azithromycin (AZM) is used in periodontal infections. The present study compared gingival crevicular fluid concentration of azithromycin of two pharmaceutical companies through the HPLC method. Methods: Two groups (n=15) of healthy volunteers participated in this study. The first group received an imported azithromycin (ImAZM) tablet (250 mg, PO) and the second group received an ...